TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Park, SeungHyun
A1  - Kim, Yong Jae
A1  - Kostal, Elisabeth
A1  - Matylitskaya, Volha
A1  - Partel, Stefan
A1  - Ryu, WonHyoung
T1  - Highly-sensitive single-step sensing of levodopa by swellable microneedle-mounted nanogap sensors
JF  - Biosensors and Bioelectronics
N2  - Microneedle (MN) sensing of biomarkers in interstitial fluid (ISF) can overcome the challenges of self-diagnosis of diseases by a patient, such as blood sampling, handling, and measurement analysis. However, the MN sensing technologies still suffer from poor measurement accuracy due to the small amount of target molecules present in ISF, and require multiple steps of ISF extraction, ISF isolation from MN, and measurement with additional equipment. Here, we present a swellable MN-mounted nanogap sensor that can be inserted into the skin tissue, absorb ISF rapidly, and measure biomarkers in situ by amplifying the measurement signals by redox cycling in nanogap electrodes. We demonstrate that the MN-nanogap sensor measures levodopa (LDA), medication for Parkinson disease, down to 100 nM in an aqueous solution, and 1 μM in both the skin-mimicked gelatin phantom and porcine skin.
KW  - Microneedle
KW  - Nanogap sensor
KW  - Redox cycling
KW  - Levodopa
KW  - Parkinson’s disease
Y1  - 2023
SN  - 1873-4235
SS  - 1873-4235
SN  - 0956-5663
SS  - 0956-5663
U6  - https://doi.org/10.1016/j.bios.2022.114912
DO  - https://doi.org/10.1016/j.bios.2022.114912
VL  - 220
SP  - 11
S1  - 11
ER  -