TY - JOUR A1 - Rank, Elisabet A. A1 - Sentosa, Ryan A1 - Harper, Danielle J. A1 - Salas, Matthias A1 - Gaugutz, Anna A1 - Seyringer, Dana A1 - Nevlacsil, Stefan A1 - Maese-Novo, Alejandro A1 - Eggeling, Moritz A1 - Muellner, Paul A1 - Hainberger, Rainer A1 - Sagmeister, Martin A1 - Kraft, Jochen A1 - Leitgeb, Rainer A. A1 - Drexler, Wolfgang T1 - Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings JF - Light: Science & Applications N2 - In this work, we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip. The diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide grating. Two arrayed waveguide grating designs with 256 channels were tested, which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal measurements. Design 1 supports a bandwidth of 22 nm, with which a sensitivity of up to 91 dB (830 µW) and an axial resolution of 10.7 µm was measured. Design 2 supports a bandwidth of 48 nm, with which a sensitivity of 90 dB (480 µW) and an axial resolution of 6.5 µm was measured. The silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process, which allows their monolithic co-integration on top of an optoelectronic silicon chip. As a benchmark for chip-based optical coherence tomography, tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip gratings. The similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system. KW - Optical coherence tomography KW - OCT KW - Arrayed waveguide gratings KW - AWG-spectrometer KW - OCT-spectrometer Y1 - 2021 U6 - http://dx.doi.org/10.1038/s41377-020-00450-0 SN - 2047-7538 VL - o. Jg. IS - H. 10/6 ER - TY - CHAP A1 - Rank, Elisabet A. A1 - Nevlacsil, Stefan A1 - Müllner, Paul A1 - Hainberger, Rainer A1 - Maese-Novo, Alejandro A1 - Dülk, Marcus A1 - Gloor, Stefan A1 - Völker, Matthias A1 - Verwaal, Nanko A1 - Meinhardt, Gerald A1 - Sagmeister, Martin A1 - Kraft, Jochen A1 - Morrissey, Padraic A1 - Jezzini, Moises A1 - Quan, Zhiheng A1 - O'Brien, Peter A1 - Richter, Stefan A1 - Kempe, Michael A1 - Seyringer, Dana A1 - Drexler, Wolfgang ED - Wojtkowski, Maciej ED - Boppart, Stephen A. ED - Oh, Wang-Yuhl T1 - Spectral domain and swept source optical coherence tomography on a photonic integrated circuit at 840nm for ophthalmic application T2 - Optical Coherence Imaging Techniques and Imaging in Scattering Media III. Event: European Conferences on Biomedical Optics, 2019, Munich, Germany Y1 - 2019 SN - 978-1-5106-2849-6 U6 - http://dx.doi.org/10.1117/12.2526903 PB - SPIE CY - Bellingham, Washington ER - TY - JOUR A1 - Seyringer, Dana A1 - Sagmeister, Martin A1 - Maese-Novo, Alejandro A1 - Eggeling, Moritz A1 - Rank, Elisabet A. A1 - Muellner, Paul A1 - Hainberger, Rainer A1 - Drexler, Wolfgang A1 - Vlaskovic, Marko A1 - Zimmermann, Horst A1 - Meinhardt, Gerald A1 - Kraft, Jochen T1 - Technological verification of size-optimized 160-channel silicon nitride-based AWG-spectrometer for medical applications JF - Applied Physics B N2 - We present the technological verification of a size-optimized 160-channel, 50-GHz silicon nitride-based AWG-spectrometer. The spectrometer was designed for TM-polarized light with a central wavelength of 850 nm applying our proprietary “AWG-Parameters” tool. For the simulations of AWG layout, the WDM PHASAR photonics tool from Optiwave was used. The simulated results show satisfying optical properties of the designed AWG-spectrometer. However, the high-channel count causes a large AWG size with standard design approaches. To solve this problem we designed a special taper enabling the reduction of AWG structure by about 15% while keeping the same optical properties. The AWG design was fabricated and the measured spectra not only confirm the proposed size-reduction but also the improvement of optical properties of the size-optimized AWG. Y1 - 2019 U6 - http://dx.doi.org/10.1007/s00340-019-7192-1 VL - 125. Jg. IS - H. 6/88 ER - TY - CHAP A1 - Seyringer, Dana A1 - Sagmeister, Martin A1 - Maese-Novo, Alejandro A1 - Eggeling, Moritz A1 - Rank, Elisabet A. A1 - Edlinger, Johannes A1 - Muellner, Paul A1 - Hainberger, Rainer A1 - Drexler, Wolfgang A1 - Kraft, Jochen A1 - Koppitsch, Guenther A1 - Meinhardt, Gerald A1 - Vlaskovic, Marko A1 - Zimmermann, Horst ED - Jaworski, Marek ED - Marciniak, Marian T1 - Compact and high-resolution 256-channel silicon nitride based AWG-spectrometer for OCT on a chip T2 - ICTON 2019. 21st International Conference on Transparent Optical Networks. 9-13 July 2019, Angers, France N2 - We present design, simulation and technological verification of a compact 256-channel, 42-GHz silicon nitride based AWG-spectrometer. The spectrometer was designed for TM-polarized light with a central wavelength of 850 nm, applying “AWG-Parameters” tool. This design is based on a previous study of various AWG designs (8-channel, 100-GHz; 20-channel, 50-GHz; 40-channel, 50-GHz, 80-channel, 50-GHz and 160-channel, 50-GHz AWGs), which were all technologically verified. The spectrometer features small size and high resolution. It is integrated on OCT chip using standard CMOS processes. The SD-OCT system is developed to operate in a wavelength range from 800 nm to 900 nm, having 0.1 nm resolution. KW - Arrayed waveguide gratings KW - high-index contrast AWG KW - Si3N4 based AWG spectrometer KW - optical coherence tomography KW - OCT on-chip Y1 - 2019 SN - 978-1-7281-2779-8 U6 - http://dx.doi.org/10.1109/ICTON.2019.8840473 PB - National Institute of Telecommunications CY - Warsaw, Poland ER -