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Highly-sensitive single-step sensing of levodopa by swellable microneedle-mounted nanogap sensors

  • Microneedle (MN) sensing of biomarkers in interstitial fluid (ISF) can overcome the challenges of self-diagnosis of diseases by a patient, such as blood sampling, handling, and measurement analysis. However, the MN sensing technologies still suffer from poor measurement accuracy due to the small amount of target molecules present in ISF, and require multiple steps of ISF extraction, ISF isolation from MN, and measurement with additional equipment. Here, we present a swellable MN-mounted nanogap sensor that can be inserted into the skin tissue, absorb ISF rapidly, and measure biomarkers in situ by amplifying the measurement signals by redox cycling in nanogap electrodes. We demonstrate that the MN-nanogap sensor measures levodopa (LDA), medication for Parkinson disease, down to 100 nM in an aqueous solution, and 1 μM in both the skin-mimicked gelatin phantom and porcine skin.

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Author:SeungHyun Park, Yong Jae Kim, Elisabeth Kostal, Volha Matylitskaya, Stefan Partel, WonHyoung Ryu
DOI:https://doi.org/10.1016/j.bios.2022.114912
ISSN:1873-4235
ISSN:0956-5663
Parent Title (English):Biosensors and Bioelectronics
Document Type:Article
Language:English
Year of publication:2023
Release Date:2024/01/31
Tag:Levodopa; Microneedle; Nanogap sensor; Parkinson’s disease; Redox cycling
Volume:220
Article Number:114912
Number of pages:11
Organisationseinheit:Forschung / Forschungszentrum Mikrotechnik
DDC classes:500 Naturwissenschaften und Mathematik / 540 Chemie
600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin, Gesundheit
Open Access?:ja
Peer review:wiss. Beitrag, peer-reviewed
Publicationlist:Matylitskaya, Volha
Partel, Stefan
Kostal, Elisabeth
Licence (German):License LogoCreative Commons - CC BY - International - Attribution- Namensnennung 4.0