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Effect of inhaled acetone concentrations on exhaled breath acetone concentrations at rest and during exercise

  • Real-time measurements of the differences in inhaled and exhaled, unlabeled and fully deuterated acetone concentration levels, at rest and during exercise, have been conducted using proton transfer reaction mass spectrometry. A novel approach to continuously differentiate between the inhaled and exhaled breath acetone concentration signals is used. This leads to unprecedented fine grained data of inhaled and exhaled concentrations. The experimental results obtained are compared with those predicted using a simple three compartment model that theoretically describes the influence of inhaled concentrations on exhaled breath concentrations for volatile organic compounds with high blood:air partition coefficients, and hence is appropriate for acetone. An agreement between the predicted and observed concentrations is obtained. Our results highlight that the influence of the upper airways cannot be neglected for volatiles with high blood:air partition coefficients, i.e. highly water soluble volatiles.

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Author:Clemens Ager, Pawel Mochalski, Julian King, Chris A. Mayhew, Karl Unterkofler
Parent Title (English):Journal of Breath Research
Document Type:Article
Year of publication:2020
Release Date:2020/11/24
Volume:14. Jg.
Issue:H. 2
Article Number:026010
Number of pages:7
Organisationseinheit:Technik / Department of Computer Science (Ende 2021 aufgelöst; Integration in die übergeordnete OE Technik)
Forschung / Forschungszentrum Business Informatics
DDC classes:500 Naturwissenschaften und Mathematik
Open Access?:ja
Publicationlist:Unterkofler, Karl
Licence (German):License LogoCreative Commons - CC BY - International - Attribution- Namensnennung 4.0