Volltext-Downloads (blau) und Frontdoor-Views (grau)
  • search hit 26 of 50
Back to Result List

Validity and reliability of the MetabQoL 1.0 and assessment of neuropsychiatric burden in organic acidemias: Reflections from Turkey

  • Objectives: The MetabQoL 1.0 is the first disease-specific health related quality of life (HrQoL) questionnaire for patients with intoxication-type inherited metabolic disorders. Our aim was to assess the validity and reliability of the MetabQoL 1.0, and to investigate neuropsychiatric burden in our patient population. Methods: Data from 29 patients followed at a single center, aged between 8 and 18 years with the diagnosis of methylmalonic acidemia (MMA), propionic acidemia (PA) or isovaleric acidemia (IVA), and their parents were included. The Pediatric Quality of Life Inventory (PedsQoL) was used to evaluate the validity and reliability of MetabQoL 1.0. Results: The MetabQoL 1.0 was shown to be valid and reliable (Cronbach's alpha: 0.64–0.9). Fourteen out of the 22 patients (63.6%) formally evaluated had neurological findings. Of note, 17 out of 20 patients (85%) had a psychiatric disorder when evaluated formally by a child and adolescent psychiatrist. The median mental scores of the MetabQoL 1.0 proxy report were significantly higher than those of the self report (p = 0.023). Patients with neonatal-onset disease had higher MetabQoL 1.0 proxy physical (p = 0.008), mental (p = 0.042), total scores (p = 0.022); and self report social (p = 0.007) and total scores (p = 0.043) than those with later onset disease. Conclusions: This study continues to prove that the MetabQoL 1.0 is an effective tool to measure what matters in intoxication-type inherited metabolic disorders. Our results highlight the importance of clinical assessment complemented by patient reported outcomes which further expands the evaluation toolbox of inherited metabolic diseases.

Export metadata

Additional Services

Search Google Scholar
Metadaten
Author:Ayse Senol Ersak, Halime Tuna Çak, Yılmaz Yıldız, Merve Kaşıkcı Çavdar, Sıla Tunç, Nagihan Özer, Nina A. Zeltner, Martina Huemer, Ayşegül Tokatlı, Göknur Haliloğlu
DOI:https://doi.org/10.1016/j.ymgme.2023.108117
ISSN:1096-7192
Parent Title (English):Molecular Genetics and Metabolism
Document Type:Article
Language:English
Year of publication:2024
Release Date:2024/02/05
Volume:141
Issue:1
Article Number:108117
Number of pages:6
First Page:1
Last Page:6
Organisationseinheit:Soziales & Gesundheit
DDC classes:600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin, Gesundheit
Open Access?:nein
Peer review:wiss. Beitrag, peer-reviewed
Publicationlist:Huemer, Martina