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Real-time measurements of the differences in inhaled and exhaled, unlabeled and fully deuterated acetone concentration levels, at rest and during exercise, have been conducted using proton transfer reaction mass spectrometry. A novel approach to continuously differentiate between the inhaled and exhaled breath acetone concentration signals is used. This leads to unprecedented fine grained data of inhaled and exhaled concentrations. The experimental results obtained are compared with those predicted using a simple three compartment model that theoretically describes the influence of inhaled concentrations on exhaled breath concentrations for volatile organic compounds with high blood:air partition coefficients, and hence is appropriate for acetone. An agreement between the predicted and observed concentrations is obtained. Our results highlight that the influence of the upper airways cannot be neglected for volatiles with high blood:air partition coefficients, i.e. highly water soluble volatiles.
Greater specific energy densities in lithium-ion batteries can be achieved by using three-dimensional (3D) porous current collectors, which allow for greater areal mass loadings of the electroactive material. In this paper, we present the use of embroidered current collectors for the preparation of thick, pouch-type Li-ion batteries. Experiments were performed on LiFePO 4 (LFP) water-based slurries using styrene-butadiene rubber (SBR) as binder and sodium carboxymethyl cellulose (CMC) as thickener, and formulations of different rheological characteristics were investigated. The electrochemical performance (cyclic voltammetry, rate capability) and morphological characteristics of the LFP half-pouch cells (X-ray micro computed tomography and scanning electron microscopy) were compared between the formulations. An optimum electrode formulation was identified, and a mechanism is proposed to explain differences between the formulations. With the optimum electrode formulation, 350 µm casted electrodes with high mechanical stability were achieved. Electrodes exhibited 4–6 times greater areal mass loadings (4–6 mAh cm −2 ) and 50% greater electroactive material weight than with foils. In tests of half- and full-pouch embroidered cells, a 50% capacity utilization at 1C-rate and 11% at 2C-rate were observed, with a full recovery at C/5-rate. The cycling stability was also maintained over 55 cycles.
Modern portable electronic devices have seen component heat load increasing, while the space available for heat dissipation has decreased. This requires the thermal management system to be optimized to attain the high performance heat sink. Heat sinks plays a major role for dissipating heat in electronic devices. Phase change material (PCM) is used to enhance the heat dissipation in heat sink. This paper reports the results of an experimental investigation of the performance of Pin fin heat sinks filled with phase change materials for thermal management of electronic devices. The experimental set ups are prepared with the graphical programming language with Lab VIEW (Laboratory Virtual Instruments for Engineering Workbench. Three different types of Pin fin Heat sink with and without PCM are investigated based on different operational timings and the temperature is acquired with the help of Data Acquisition Card (DAQ). The results indicated that the inclusion of the PCM could stabilize the temperature for a longer period and reduce the heating rates and peak temperatures of heat sink with increasing the number of fins can enhance the thermal performance of electronic devices.
Gas hydrates are usually synthesized by bringing together a pressurized gas and liquid or solid water. In both cases, the transport of gas or water to the hydrate growth site is hindered once an initial film of hydrate has grown at the water–gas interface. A seemingly forgotten gas-phase technique overcomes this problem by slowly depositing water vapor on a cold surface in the presence of the pressurized guest gas. Despite being used for the synthesis of low-formation-pressure hydrates, it has not yet been tested for hydrates of CO 2 and CH 4 . Moreover, the potential of the technique for the study of hydrate decomposition has not been recognized yet. We employ two advanced implementations of the condensation technique to form hydrates of CO 2 and CH 4 and demonstrate the applicability of the process for the study of hydrate decomposition and the phenomenon of self-preservation. Our results show that CO 2 and CH 4 hydrate samples deposited on graphite at 261–265 K are almost pure hydrates with an ice fraction of less than 8%. Rapid depressurization experiments with thin deposits (approx. 330 mm thickness) of CO 2 hydrate on an aluminum surface at 265 K yield identical dissociation curves when the deposition is done at identical pressure. However, hydrates deposited at 1 MPa almost completely withstand decomposition after rapid depressurization to 0.1 MPa, while samples deposited at 2 MPa decompose 7 times faster. Therefore, this synthesis technique is not only applicable for the study of hydrate decomposition but can also be used for the controlled deposition of a super-preserved hydrate.
Activation of heat pump flexibilities is a viable solution to support balancing the grid via Demand Side Management measures and fulfill the need for flexibility options. Aggregators as interface between prosumers, distribution system operators and balance responsible parties face the challenge due to data privacy and technical restrictions to transform prosumer information into aggregated available flexibility to enable trading thereof. Thereby, literature lacks a generic, applicable and widely accepted flexibility estimation method for heat pumps,which incorporates reduced sensor and system information, system- and demand-dependent behaviour. In this paper, we adapt and extend a method from literature, by incorporating domain knowledge to overcome reduced sensor and system information. We apply data of five real-world heat pump systems, distinguish operation modes, estimate power and energy flexibility of each single heat pump system, proof transferability of the method, and aggregate the flexibilities available to showcase a small HP pool as a proof of concept.
For a given set of banks, how big can losses in bad economic or financial scenarios possibly get, and what are these bad scenarios? These are the two central questions of stress tests for banks and the banking system. Current stress tests select stress scenarios in a way which might leave aside many dangerous scenarios and thus create an illusion of safety; and which might consider highly implausible scenarios and thus trigger a false alarm. We show how to select scenarios systematically for a banking system in a context of multiple credit exposures. We demonstrate the application of our method in an example on the Spanish and Italian residential real estate exposures of European banks. Compared to the EBA 2016 stress test our method produces scenarios which are equally plausible as the EBA stress scenario but yield considerably worse system wide losses.
Recently the use of microRNAs (miRNAs) as biomarkers for a multitude of diseases has gained substantial significance for clinical as well as point-of-care diagnostics. Amongst other challenges, however, it holds the central requirement that the concentration of a given miRNA must be evaluated within the context of other factors in order to unambiguously diagnose one specific disease. In terms of the development of diagnostic methods and devices, this implies an inevitable demand for multiplexing in order to be able to gauge the abundance of several components of interest in a patient’s sample in parallel. In this study, we design and implement different multiplexed versions of our electrochemical microfluidic biosensor by dividing its channel into subsections, creating four novel chip designs for the amplification-free and simultaneous quantification of up to eight miRNAs on the CRISPR-Biosensor X (‘X’ highlighting the multiplexing aspect of the device). We then use a one-step model assay followed by amperometric readout in combination with a 2-minute-stop-flow-protocol to explore the fluidic and mechanical characteristics and limitations of the different versions of the device. The sensor showing the best performance, is subsequently used for the Cas13a-powered proof-of-concept measurement of two miRNAs (miRNA-19b and miRNA-20a) from the miRNA-17∼92 cluster, which is dysregulated in the blood of pediatric medulloblastoma patients. Quantification of the latter, alongside simultaneous negative control measurements are accomplished on the same device. We thereby confirm the applicability of our platform to the challenge of amplification-free, parallel detection of multiple nucleic acids.
The goal of this paper is to design a low-loss 1 x 32 Y-branch optical splitter for optical transmission systems, using two different design tools employing Beam Propagation Method. As a first step, a conventional 1 x 32 Y-branch splitter was designed and simulated in two-dimensional environment of OptiBPM photonic tool. The simulated optical properties feature high loss, high asymmetric splitting ratio and a large size of the designed structure, too. In the second step of this work we propose an optimization of the conventional splitter design leading to suppression of the asymmetric splitting ratio to one-third of its initial value and to the improvement of the losses by nearly 2 dB. In addition, 50% size reduction of the designed structure was also achieved. This length-optimized low-loss splitter was then modelled in a three-dimensional environment of RSoft photonic tool and the simulated results confirm the strong improvement of the optical properties.
Transparent laser-structured glasses with superhydrophilic properties for anti-fogging applications
(2019)
Ultrashort pulse laser structuring enables direct modification of glass surfaces to generate superhydrophilic properties for anti-fogging applications. This approach makes coatings dispensable and the generated surfaces remain thermally, mechanically, and chemically resistant. However, the laser-generated structures usually cause scattering, which decreases transmission and may disturb the vision through the modified glass in the dry state. The aim of this study was to find a laser-processing strategy to achieve superhydrophilic, anti-fogging properties on glass surfaces with maximum transmission and minimal visual perception of the generated structure. For this purpose, we used an ultrashort-pulsed laser to generate periodic patterns of rippled circles or rough holes with varying pitch. The water contact angle and transmission of the structured glasses were measured as a function of the structured area. It was found that a periodic pattern of holes, which covers less than 1% of the surface, is already sufficient to reach the superhydrophilic state (contact angle < 5°) and provides nearly the same transmission as pristine glass. Pictures of objects imaged through dry, structured glasses, which were placed close to the lens or object, showed in both cases only a minimal decrease of contrast. If this minor drawback can be accepted, this direct laser structuring approach could be an interesting alternative to coating-based techniques and leaves even room to apply additional coatings for the fabrication of multi-functional special glasses.
Vast amounts of oily wastewater are byproducts of the petrochemical and the shipping industry and to this day frequently discharged into water bodies either without or after insufficient treatment. To alleviate the resulting pollution, water treatment processes are in great demand. Bubble column humidifiers (BCHs) as part of humidification–dehumidification systems are predestined for such a task, since they are insensitive to different feed liquids, simple in design and have low maintenance requirements. While humidification in a bubble column has been investigated plentiful for desalination, a systematic investigation of oily wastewater treatment is missing in literature. We filled this gap by analyzing the treatment of an oil–water emulsion experimentally to derive recommendations for future design and operation of BCHs. Our humidity measurements indicate that the air stream is always saturated after humidification for a liquid height of only 10 cm. A residual water mass fraction of 3.5 wt% is measured after a batch run of six hours. Furthermore, continuous measurements show that an increase in oil mass fraction leads to a decrease in system productivity especially for high oil mass fractions. This decrease is caused by the heterogeneity of the liquid temperature profile. A lower liquid height mitigates this heterogeneity, therefore decreasing the heat demand and improving the overall efficiency. The oil content of the produced condensate is below 15 ppm, allowing discharge into various water bodies. The results of our systematic investigation prove suitability and indicate a strong future potential for the use of BCHs in oily wastewater treatment.
Bubble columns are recently used for the humidification of air in water treatment systems and fuel cells. They are well applicable due to their excellent heat and mass transfer and their low technical complexity. To design and operate such devices with high efficiency, the humidification process and the impact of the operating parameters need to be understood to a sufficient degree. To extend this knowledge, we use a refined and novel method to determine the volumetric air–liquid heat and mass transfer coefficients and the humidifier efficiency for various parametric settings. The volumetric transfer coefficients increase with both of the superficial air velocity and the liquid temperature. It is further shown that the decrease of vapor pressure with an increase of the salinity results in a corresponding decrease in the outlet humidity ratio. In contrast to previous studies, liquid heights smaller than 0.1 m are investigated and significant changes in the humidifier efficiency are seen in this range. We present the expected humidifier efficiency with respect to the superficial air velocity and the liquid height in an efficiency chart, such that optimal operating conditions can be determined. Based on this efficiency chart, recommendations for industrial applications as well as future scientific challenges are drawn.
The humidification-dehumidification process (HDH) for desalination is a promising technology to address water scarcity issues in rural regions. However, a low humidifier efficiency is a weakness of the process. Bubble column humidifiers (BCH) are promising for HDH, as they provide enhanced heat and mass transfer and have low maintenance requirements. Previous studies of HDH-systems with BCHs draw different conclusions regarding the impact of superficial air velocity and liquid height on the humidification. Furthermore, the impact of flow characteristics has never been investigated systematically at all. In this study, an optimized BCH test setup that allows for optical analysis of the humidifier is used and evaluated. Our test setup is validated, since the influence of water temperature on the humidification, which is exponential, is reproduced. Measurements with seawater show that the normalised system productivity is increased by about 56 % with an increase in superficial air velocity from 0.5 to 5 cm/s. Furthermore, the system productivity is increased by around 29 % with an increase in liquid height from 60 to 378 mm. While the impact of superficial air velocity can be traced back to temperature changes at the humidifier and dehumidifier outlets, the impact of liquid height is shown to be caused by a smaller heat loss surface in the humidifier with an increase in liquid height. For the impact of sieve plate orifice diameter, a clear influence on the humidification is not apparent, this parameter needs to be investigated further. Finally, our new test setup allows for analysing the humidification of air (1) in a systematic way, (2) in relevant measurement ranges and (3) in comparison with optical analyses of the flow characteristics.
In engineering design, optimization methods are frequently used to improve the initial design of a product. However, the selection of an appropriate method is challenging since many
methods exist, especially for the case of simulation-based optimization. This paper proposes a systematic procedure to support this selection process. Building upon quality function deployment, end-user and design use case requirements can be systematically taken into account via a decision
matrix. The design and construction of the decision matrix are explained in detail. The proposed
procedure is validated by two engineering optimization problems arising within the design of box-type boom cranes. For each problem, the problem statement and the respectively applied optimization methods are explained in detail. The results obtained by optimization validate the use
of optimization approaches within the design process. The application of the decision matrix shows the successful incorporation of customer requirements to the algorithm selection.
We have demonstrated micromachining of bulk 3C silicon carbide (3C- SiC) wafers by employing 1028nm wavelength femtosecond laser pulses of energy less than 10 nJ directly from a femtosecond laser oscillator, thus eliminating the need for an amplified system and increasing the micromachining speed by more than four orders of magnitude.
Mobility choices - an instrument for precise automatized travel behavior detection & analysis
(2021)
Organic acidurias (OAs), urea-cycle disorders (UCDs), and maple syrup urine disease (MSUD) belong to the category of intoxication-type inborn errors of metabolism (IT-IEM). Liver transplantation (LTx) is increasingly utilized in IT-IEM. However, its impact has been mainly focused on clinical outcome measures and rarely on health-related quality of life (HRQoL). Aim of the study was to investigate the impact of LTx on HrQoL in IT-IEMs. This single center prospective study involved 32 patients (15 OA, 11 UCD, 6 MSUD; median age at LTx 3.0 years, range 0.8–26.0). HRQoL was assessed pre/post transplantation by PedsQL-General Module 4.0 and by MetabQoL 1.0, a specifically designed tool for IT-IEM. PedsQL highlighted significant post-LTx improvements in total and physical functioning in both patients' and parents' scores. According to age at transplantation (≤3 vs. >3 years), younger patients showed higher post-LTx scores on Physical (p = 0.03), Social (p < 0.001), and Total (p =0.007) functioning. MetabQoL confirmed significant post-LTx changes in Total and Physical functioning in both patients and parents scores (p ≤ 0.009). Differently from PedsQL, MetabQoL Mental (patients p = 0.013, parents p = 0.03) and Social scores (patients p = 0.02, parents p = 0.012) were significantly higher post-LTx. Significant improvements (p = 0.001–0.04) were also detected both in self- and proxy-reports for almost all MetabQoL subscales. This study shows the importance of assessing the impact of transplantation on HrQoL, a meaningful outcome reflecting patients' wellbeing. LTx is associated with significant improvements of HrQol in both self- and parentreports. The comparison between PedsQL-GM and MetabQoL highlighted that MetabQoL demonstrated higher sensitivity in the assessment of diseasespecific domains than the generic PedsQL tool.
The production of liquid-gas mixtures with desired properties still places high demands on process technology and is usually realized in bubble columns. The physical calculation models used have individual dimensionless factors which, depending on the application, are only valid for small ranges consisting of flow velocity, nozzle geometry and test setup. An iterative but time-consuming design of such dispersion processes is used in industry for producing a liquid-gas mixture according to desired requirements. In the present investigation, we accelerate the necessary design loops by setting up a physical model, which consists of several subsystems that are enriched by dedicated experiments to realize liquid-gas dispersions with low volume fraction and small air bubble diameters in oil. Our approach allows the extraction of individual dimensionless factors from maps of the introduced subsystems. These maps allow for targeted corrective measures of a production process for keeping the quality. The calculation-based approach avoids the need for performing iterative design loops. Overall, this approach supports the controlled generation of liquid-gas mixtures.
The production of liquid-gas dispersions places high demands on the process technology, which requires knowledge of the bubble formation mechanisms, as well as the phase parameters of the media combinations used. To obtain the bubble sizes introduced to a flow not knowing the phase parameters, different process parameters are investigated. Their quality and applicability are evaluated. The results obtained make it possible to simplify long design processes of dispersion processes in manufacturing plants and to ensure the product quality of the products manufactured, by reducing waste.
Grid-scale electrical energy storage (EES) is a key component in cost-effective transition scenarios to renewable energy sources. The requirement of scalability favors EES approaches such as pumped-storage hydroelectricity (PSH) or compressed-air energy storage (CAES), which utilize the cheap and abundant storage materials water and air, respectively. To overcome the site restriction and low volumetric energy densities attributed to PSH and CAES, liquid-air energy storage (LAES) has been devised; however, it suffers from a rather small round-trip efficiency (RTE) and challenging storage conditions. Aiming to overcome these drawbacks, a novel system for EES is developed using solidified air (i.e., clathrate hydrate of air) as the storable phase of air. A reference plant for solidified-air energy storage (SAES) is conceptualized and modeled thermodynamically using the software CoolProp for water and air as well as empirical data and first-order approximations for the solidified air (SA). The reference plant exhibits a RTE of 52% and a volumetric storage density of 47 kWh per m3 of SA. While this energy density relates to only one half of that in LAES plants, the modeled RTE of SAES is comparable already. Since improved thermal management and the use of thermodynamic promoters can further increase the RTEs in SAES, the technical potential of SAES is in place already. Yet, for a successful implementation of the concept - in addition to economic aspects - questions regarding the stability of SA must be first clarified and challenges related to the processing of SA resolved.
Zusammenfassung: Eine umfassende Literaturrecherche (Comprehensive Literature Search, CLS) bezeichnet eine umfangreiche und aufwändige Recherche mit dem Ziel, möglichst alle Studien zur Beantwortung einer zugrundeliegenden Forschungsfrage im Rahmen einer systematischen Übersichtsarbeit zu identifizieren. Konkrete Empfehlungen oder eine Definition des Begriffs CLS gibt es jedoch nicht. Der vorliegende Beitrag führt in eine Rahmung der CLS ein, stellt die damit einhergehenden Herausforderungen dar und weist auf methodische Implikationen sowie mögliche zukünftige Forschungsbereiche hin.
Measuring what matters
(2023)
Patient reported outcomes (PROs) are generally defined as ‘any report of the status of a patient's health condition that comes directly from the patient, without interpretation of the patient's response by a clinician or anyone else’. A broader definition of PRO also includes ‘any information on the outcomes of health care obtained directly from patients without modification by clinicians or other health care professionals’. Following this approach, PROs encompass subjective perceptions of patients on how they function or feel not only in relation to a health condition but also to its treatment as well as concepts such as health-related quality of life (HrQoL), information on the functional status of a patient, signs and symptoms and symptom burden. PRO measurement instruments (PROMs) are mostly questionnaires and inform about what patients can do and how they feel. PROs and PROMs have not yet found unconditional acceptance and wide use in the field of inborn errors of metabolism. This review summarises the importance and usefulness of PROs in research, drug legislation and clinical care and informs about quality standards, development, and potential methodological shortfalls of PROMs. Inclusion of PROs measured with high-quality, well-selected PROMs into clinical care, drug legislation, and research helps to identify unmet needs, improve quality of care, and define outcomes that are meaningful to patients. The field of IEM should open to new methodological approaches such as the definition of core sets of variables including PROs to be systematically assessed in specific metabolic conditions and new collaborations with PRO experts, such as psychologists to facilitate the systematic collection of meaningful data.
If left uncontrolled, electric vehicle charging poses severe challenges to distribution grid operation. Resulting issues are expected to be mitigated by charging control. In particular, voltage-based charging control, by relying only on the local measurements of voltage at the point of connection, provides an autonomous communication-free solution. The controller, attached to the charging equipment, compares the measured voltage to a reference voltage and adapts the charging power using a droop control characteristic. We present a systematic study of the voltage-based droop control method for electric vehicles to establish the usability of the method for all the currently available residential electric vehicle charging possibilities considering a wide range of electric vehicle penetrations. Voltage limits are evaluated according to the international standard EN50160, using long-term load flow simulations based on a real distribution grid topology and real load profiles. The results achieved show that the voltage-based droop controller is able to mitigate the under voltage problems completely in distribution grids in cases either deploying low charging power levels or exhibiting low penetration rates. For high charging rates and high penetrations, the control mechanism improves the overall voltage profile, but it does not remedy the under voltage problems completely. The evaluation also shows the controller’s ability to reduce the peak power at the transformer and indicates the impact it has on users due to the reduction in the average charging rates. The outcomes of the paper provide the distribution grid operators an insight on the voltage-based droop control mechanism for the future grid planning and investments.
Increasing electric vehicle penetration leads to undesirable peaks in power if no proper coordination in charging is implemented. We tested the feasibility of electric vehicles acting as flexible demands responding to power signals to minimize the system peaks. The proposed hierarchical autonomous demand side management algorithm is formulated as an optimal power tracking problem. The distribution grid operator determines a power signal for filling the valleys in the non-electric vehicle load profile using the electric vehicle demand flexibility and sends it to all electric vehicle controllers. After receiving the control signal, each electric vehicle controller re-scales it to the expected individual electric vehicle energy demand and determines the optimal charging schedule to track the re-scaled signal. No information concerning the electric vehicles are reported back to the utility, hence the approach can be implemented using unidirectional communication with reduced infrastructural requirements. The achieved results show that the optimal power tracking approach has the potential to eliminate additional peak demands induced by electric vehicle charging and performs comparably to its central implementation. The reduced complexity and computational overhead permits also convenient deployment in practice.
Open tracing tools
(2023)
Background: Coping with the rapid growing complexity in contemporary software architecture, tracing has become an increasingly critical practice and been adopted widely by software engineers. By adopting tracing tools, practitioners are able to monitor, debug, and optimize distributed software architectures easily. However, with excessive number of valid candidates, researchers and practitioners have a hard time finding and selecting the suitable tracing tools by systematically considering their features and advantages. Objective: To such a purpose, this paper aims to provide an overview of popular Open tracing tools via comparison. Methods: Herein, we first identified 30 tools in an objective, systematic, and reproducible manner adopting the Systematic Multivocal Literature Review protocol. Then, we characterized each tool looking at the 1) measured features, 2) popularity both in peer-reviewed literature and online media, and 3) benefits and issues. We used topic modeling and sentiment analysis to extract and summarize the benefits and issues. Specially, we adopted ChatGPT to support the topic interpretation. Results: As a result, this paper presents a systematic comparison amongst the selected tracing tools in terms of their features, popularity, benefits and issues. Conclusion: The result mainly shows that each tracing tool provides a unique combination of features with also different pros and cons. The contribution of this paper is to provide the practitioners better understanding of the tracing tools facilitating their adoption.
Praxisanleiter:innen nehmen eine entscheidende Rolle in der Ausbildung von Pflegepersonen wahr. Die Tätigkeit fordert eine Vielzahl von Kompetenzen. Die Weiterbildung Praxisanleitung bietet eine wichtige Grundlage für die Entwicklung dieser Kompetenzen – deren Rahmenbedingungen, Methoden und Inhalte in Österreich werden in dieser Studie untersucht.
This paper presents a project developed at the K.S.Rangasamy College of Technology (Tamilnadu,India) aimed at designing, implementing, and testing an autonomous multipurpose vehicle with safe, efficient, and economic operation. This autonomous vehicle moves through the crop lines of a Agricultural land and performs tasks that are tedious and/or hazardous to the farmers. First, it has been equipped for spraying, but other configurations have also been designed, such as: a seeding ,plug platform to reach the top part of the plants to perform different tasks (pruning, harvesting, etc.), and a trailer to transport the fruits, plants, and crop waste.
Verbraucherseitige Laststeuerung (Demand Side Management – DSM) wird als ein möglicher Ansatz betrachtet, um die Auswirkungen des Ausbaus von fluktuierenden Erneuerbaren im Stromnetz auszugleichen. Sollen viele verteilte Energiesysteme damit angesprochen werden, stellen zentralistische Ansätze dabei hohe Anforderungen an die Kommunikationsinfrastruktur. Als Alternative wird vielfach eine autonome Laststeuerung (ADSM) mit anreizbasierter Optimierung direkt auf dem Verbrauchergerät betrachtet. Dabei kann die Anreizfunktion mittels unidirektionaler Kommunikation übertragen werden.
Am Forschungszentrum Energie der Fachhochschule Vorarlberg wurden in den letzten Jahren Algorithmen und Prototypen für den Einsatz von ADSM auf verschiedensten verteilten Energiespeichern im elektrischen Stromnetz entwickelt. Dabei werden sowohl thermische Energiespeicher (z. B. Haushalts-Warmwasserspeicher) als auch elektrochemische Speicher (z. B. Batteriespeichersysteme oder Elektroautos) betrachtet. Außerdem werden die Auswirkungen solcher Systeme auf das elektrische Verteilnetz untersucht. Dieser Artikel gibt einen Überblick über die entwickelten Methoden und Ergebnisse aus diesem Forschungsfeld mit dem Ziel, ein weitreichendes Verständnis für die Chancen und Grenzen des ADSM zu schaffen.
In previous studies of linear rotary systems with active magnetic bearings, parametric excitation was introduced as an open-loop control strategy. The parametric excitation was realized by a periodic, in-phase variation of the bearing stiffness. At the difference between two of the eigenfrequencies of the system, a stabilizing effect, called anti-resonance, was found numerically and validated in experiments. In this work, preliminary results of further exploration of the parametric excitation are shared. A Jeffcott rotor with two active magnetic bearings and a disk is investigated. Using Floquet theory, a deeper insight into the dynamic behavior of the system is obtained. Aiming at a further increase of stability, a phase difference between excitation terms is introduced.
Zu Beginn des Forschungsprojektes „Neue Museumswelten“ wollten wir von Studierenden der Studiengänge Bachelor und Master InterMedia an der Fachhochschule Vorarlberg wissen, was sie mit dem Begriff „Museum“ verbinden. „Museum? Da gehe ich nur im Urlaub hin. Aber hier in Vorarlberg nicht“, war eine geläufige Aussage, die auf ein bestimmtes mentales Modell von Museum verweist. Viele Studierenden gehören also der Gruppe der Gelegenheits- oder Nichtbesucher:innen an. Wie sich in weiterer Folge herausstellte, handelt es sich dabei um eine durchaus heterogene Gruppe, die jedoch auch Gemeinsamkeiten aufweist: Alle Menschen, mit denen wir bisher im Zuge des Forschungsprojekts im Stadtraum, auf Events und im Museum sprachen, spielten und Zukunftsvisionen entwickelten, brachten ihre eigenen Bilder, Vorstellungen und Ideen zu Museen und möglichen Museumszukünften mit. Der Untersuchung genau dieser Bilder und Vorstellungen – der mentalen Modelle von Museum also –, widmet sich das von Interreg geförderte Forschungsprojekt unter Einbindung vielfältiger Perspektiven und Methoden aus Sozialforschung und Design. Es verfolgt den innovativen Weg, „Designerly Ways of Knowing“0 von Beginn an konsequent in den Forschungsprozess zu integrieren, um anstrebenswerte Museumszukünfte gemeinsam mit den Menschen auszuloten...
Entangled photon generation at 1550 nm in the telecom C-band is of critical importance as it enables the realization of quantum communication protocols over long distance using deployed telecommunication infrastructure. InAs epitaxial quantum dots have recently enabled on-demand generation of entangled photons in this wavelength range. However, time-dependent state evolution, caused by the fine-structure splitting, currently limits the fidelity to a specific entangled state. Here, we show fine-structure suppression for InAs quantum dots using micromachined piezoelectric actuators and demonstrate generation of highly entangled photons at 1550 nm. At the lowest fine-structure setting, we obtain a maximum fidelity of 90.0 ± 2.7% (concurrence of 87.5 ± 3.1%). The concurrence remains high also for moderate (weak) temporal filtering, with values close to 80% (50%), corresponding to 30% (80%) of collected photons, respectively. The presented fine-structure control opens the way for exploiting entangled photons from quantum dots in fiber-based quantum communication protocols.
Violation-mitigation-based method for PV hosting capacity quantification in low voltage grids
(2022)
Hosting capacity knowledge is of great importance for distribution utilities to assess the amount of PV capacity possible to accommodate without troubling the operation of the grid. In this paper, a novel method to quantify the hosting capacity of low voltage grids is presented. The method starts considering a state of fully exploited building rooftop solar potential. A downward process is proposed - from the starting state with expected violations on the grid operation to a state with no violations. In this process, the installed PV capacity is progressively reduced. The reductions are made sequentially and selectively aiming to mitigate specific violations: nodes overvoltage, lines overcurrent and transformer overloading. Evaluated on real data of fourteen low voltage grids from Austria, the method proposed exhibits benefits in terms of higher hosting capacities and lower computational costs compared to stochastic methods. Furthermore, it also quantifies hosting capacity expansions achievable by overcoming the effect of the violations. The usage of a potential different from solar rooftops is also presented, demonstrating that a user-defined potential allows to quantify the hosting capacity in a more general setting with the method proposed.
Background: The development of mobile interventions for noncommunicable diseases has increased in recent years. However, there is a dearth of apps for patients with peripheral arterial disease (PAD), who frequently have an impaired ability to walk.
Objective: Using a patient-centered approach for the development of mobile interventions, we aim to describe the needs and requirements of patients with PAD regarding the overall care situation and the use of mobile interventions to perform supervised exercise therapy (SET).
Methods: A questionnaire survey was conducted in addition to a clinical examination at the vascular outpatient clinic of the West-German Heart and Vascular Center of the University Clinic Essen in Germany. Patients with diagnosed PAD were asked to answer questions on sociodemographic characteristics, PAD-related need for support, satisfaction with their health care situation, smartphone and app use, and requirements for the design of mobile interventions to support SET.
Results: Overall, a need for better support of patients with diagnosed PAD was identified. In total, 59.2% (n=180) expressed their desire for more support for their disease. Patients (n=304) had a mean age of 67 years and half of them (n=157, 51.6%) were smartphone users. We noted an interest in smartphone-supported SET, even for people who did not currently use a smartphone. “Information,” “feedback,” “choosing goals,” and “interaction with physicians and therapists” were rated the most relevant components of a potential app.
Conclusions: A need for the support of patients with PAD was determined. This was particularly evident with regard to disease literacy and the performance of SET. Based on a detailed description of patient characteristics, proposals for the design of mobile interventions adapted to the needs and requirements of patients can be derived.
Post-operative isoflurane has been observed to be present in the end-tidal breath of patients who have undergone major surgery, for several weeks after the surgical procedures. A major new noncontrolled, non-randomized, and open-label approved study will recruit patients undergoing various surgeries under different inhalation anaesthetics, with two key objectives, namely to record the washout characteristics following surgery, and to investigate the influence of a patient’s health and the duration and type of surgery on elimination. In preparation for this breath study using proton transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS), it is important to identify first the analytical product ions that need to be monitored and under what operating conditions. In this first paper of this new research programme, we present extensive PTR-TOF-MS studies of three major
anaesthetics used worldwide, desflurane (CF3CHFOCHF2), sevoflurane ((CF3)2CHOCH2F), and isoflurane (CF3CHClOCHF2) and a fourth one, which is used less extensively, enflurane (CHF2OCF2CHFCl), but is of interest because it is an isomer of isoflurane. Product ions are identified as a function of reduced electric field (E/N) over the range of approximately 80 Td to 210 Td, and the effects of operating the drift tube under ‘normal’ or ‘humid’ conditions on the intensities of the product ions are presented. To aid in the analyses, density functional theory (DFT) calculations of the proton affinities and the gas-phase basicities of the anaesthetics have been determined. Calculated energies for the ion-molecule reaction pathways leading to key product ions, identified as ideal for monitoring the inhalation anaesthetics in breath with a high sensitivity and selectivity, are also presented.
The impact of global warming and climate change has forced countries to introduce strict policies and decarbonization goals toward sustainable development. To achieve the decarbonization of the economy, a substantial increase of renewable energy sources is required to meed energy demand and to transition away from fossil fuels. However, renewables are sensitive to environmental conditions, which may lead to imbalances between energy supply and demand. Battery energy storage systems are gaining more attention for balancing energy systems in existing grid networks at various levels such as bulk power management, transmission and distribution, and for end-users. Integrating battery energy storage systems with renewables can also solve reliability issues related to transient energy production and be used as a buffer source for electrical vehicle fast charging. Despite these advantages, batteries are still expensive and typically built for a single application – either for an energy- or power-dense application – which limits economic feasibility and flexibility. This paper presents a theoretical approach of a hybrid energy storage system that utilizes both energy- and power-dense batteries serving multiple grid applications. The proposed system will employ second use electrical vehicle batteries in order to maximise the potential of battery waste. The approach is based on a survey of battery modelling techniques and control methods. It was found that equivalent circuit models as well as unified control methods are best suited for modelling hybrid energy storages for grid applications. This approach for hybrid modelling is intended to help accelerate the renewable energy transition by providing reliable energy storage.
The Digital Factory Vorarlberg is the youngest Research Center of Vorarlberg University of Applied Sciences. In the lab of the research center a research and learning factory has been established for educating students and employees of industrial partners. Showcases and best practice scenarios for various topics of digitalization in the manufacturing industry are demonstrated. In addition, novel methods and technologies for digital production, cloud-based manufacturing, data analytics, IT- and OT-security or digital twins are being developed. The factory comprises only a minimum core of logistics and fabrication processes to guarantee manageability within an academic setup. As a product, fidget spinners are being fabricated. A webshop allows customers to individually design their products and directly place orders in the factory. A centralized SCADA-System is the core data hub for the factory. Various data analytic tools and methods and a novel database for IoT-applications are connected to the SCADA-System. As an alternative to on premise manufacturing, orders can be pushed into a cloud-based manufacturing platform, which has been developed at the Digital Factory. A broker system allows fabrication in distributed facilities and offers various optimization services. Concepts, such as outsourcing product configuration to customers or new types of engineering services in cloud-based manufacturing can be explored and demonstrated. In this paper, we present the basic concept of the Digital Factory Vorarlberg, as well as some of the newly developed topics.
In this paper, we propose and simulate a new type of three-dimensional (3D) optical splitter based on multimode interference (MMI) for the wavelength of 1550 nm. The splitter was proposed on the square basis with the width of 20 x 20 µm2 using the IP-Dip polymer as a standard material for 3D laser lithography. We present the optical field distribution in the proposed MMI splitter and its integration possibility on optical fiber. The design is aimed to the possible fabrication process using the 3D laser lithography for forthcoming experiments.
Breath analysis offers a non-invasive and rapid diagnostic method for detecting various volatile organic compounds that could be indicators for different diseases, particularly metabolic disorders including type 2 diabetes mellitus. The development of type 2 diabetes mellitus is closely linked to metabolic dysfunction of adipose tissue and adipocytes. However, the VOC profile of human adipocytes has not yet been investigated. Gas chromatography with mass spectrometric detection and head-space needle trap extraction (two-bed Carbopack X/Carboxen 1000 needle traps) were applied to profile VOCs produced and metabolised by human Simpson Golabi Behmel Syndrome adipocytes. In total, sixteen compounds were identified to be related to the metabolism of the cells. Four sulphur compounds (carbon disulphide, dimethyl sulphide, ethyl methyl sulphide and dimethyl disulphide), three heterocyclic compounds (2-ethylfuran, 2-methyl-5-(methyl-thio)-furan, and 2-pentylfuran), two ketones (acetone and 2-pentanone), two hydrocarbons (isoprene and n-heptane) and one ester (ethyl acetate) were produced, and four aldehydes (2-methyl-propanal, butanal, pentanal and hexanal) were found to be consumed by the cells of interest. This study presents the first profile of VOCs formed by human adipocytes, which may reflect the activity of the adipose tissue enzymes and provide evidence of their active role in metabolic regulation. Our data also suggest that a previously reported increase of isoprene and sulphur compounds in diabetic patients may be explained by their production by adipocytes. Moreover, the unique features of this profile, including a high emission of dimethyl sulphide and the production of furan-containing VOCs, increase our knowledge about metabolism in adipose tissue and provide diagnostic potential for future applications.
Product ion distributions resulting from the primary reactions of H3O+ with nine D-labeled volatile organic compounds and the subsequent sequential reactions with H2O have been determined using a Proton Transfer Reaction Time of Flight Mass Spectrometer (PTR-TOF 8000 (IONICON Analytik GmbH)) at various reduced electric field (E/N) values ranging from 80 up to 150 Td and for two different absolute humidity levels of air sample < 0.1% and 5%. The specific D-labeled compounds used in this study are acetone-d6, toluene-d8, benzene-d6, ethanol-d (C2H5OD), ethanol-d2 (CH3CD2OH), ethanol-d6, 2-propanol-d8, 2-propanol-d3 (CD3CH(OH)CH3), and isoprene-d5 (CH2CHC(CD2)CD3). With the exception of the two 2-propanol compounds, non-dissociative proton transfer is the dominant primary reaction pathway. For 2-propanol-d8 and 2-propanol-d3 the major primary reaction channel involved is dissociative proton transfer. However, unlike their undeuterated counterparts, the primary product ions undergo subsequent deuterium/hydrogen isotope exchange reactions with the ever present water in the drift tube, the extent of which of course depends on the humidity within that tube. This exchange leads to the generation of various isotopologue product ions, the product ion branching percentages of which are also
dependent on the humidity in the drift tube. This results in complex mass spectra and the distribution of product ions leads to issues of reduced sensitivity and accuracy. However, the effect of D/H exchange considerably varies between the compounds under study. In the case of acetone-d6 it is very weak (<1%), because the exchange process is not facile when the deuterium is in the methyl functional group. In comparison, the H3O+/ benzene-d6 (C6D6) reaction and sequential reactions with water result in the production of the isotopologue ions C6Dn(H7-n)+ (where n = 0–6). Changing the value of E/N and/or the humidity in the drift tube considerably affects the amount of the isotope exchange reactions and hence the resulting sequential product ion distributions. An important conclusion of the findings from this work is that care must be taken in the choice of an exogenous deuterated compound for use in breath pharmacokinetic studies using proton transfer reaction mass spectrometry; otherwise the resulting D/H exchange processes impose interpretative problems.
© 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).
Breath analysis holds great promise for real-time and non-invasive medical diagnosis. Thus, there is a considerable need for simple-in-use and portable analyzers for rapid detection of breath indicators for different diseases in their early stages. Sensor technology meets all of these demands. However, miniaturized breath analyzers require adequate breath sampling methods. In this context, we propose non-contact sampling; namely the collection of breath samples by exhalation from a distance into a miniaturized collector without bringing the mouth into direct contact with the analyzing device. To evaluate this approach different breathing maneuvers have been tested in a real-time regime on a cohort of 23 volunteers using proton transfer reaction mass spectrometry. The breathing maneuvers embraced distinct depths of respiration, exhalation manners, size of the mouth opening and different sampling distances. Two inhalation modes (normal, relaxed breathing and deep breathing) and two exhalation manners (via smaller and wider lips opening) forming four sampling scenarios were selected. A sampling distance of approximately 2 cm was found to be a reasonable trade-off between sample dilution and requirement of no physical contact of the subject with the analyzer. All four scenarios exhibited comparable measurement reproducibility spread of around 10%. For normal, relaxed inspiration both dead-space and end-tidal phases of exhalation lasted approximately 1.5 s for both expiration protocols. Deep inhalation prolongs the end-tidal phase to about 3 s in the case of blowing via a small lips opening, and by 50% when the air is exhaled via a wide one. In conclusion, non-contact breath sampling can be considered as a promising alternative to the existing breath sampling methods, being relatively close to natural spontaneous breathing.
X-ray microtomography is a nondestructive, three-dimensional inspection technique applied across a vast range of fields and disciplines, ranging from research to industrial, encompassing engineering, biology, and medical research. Phasecontrast imaging extends the domain of application of x-ray microtomography to classes of samples that exhibit weak attenuation, thus appearing with poor contrast in standard x-ray imaging. Notable examples are low-atomic-number materials, like carbon-fiber composites, soft matter, and biological soft tissues.We report on a compact and cost-effective system for x-ray phase-contrast microtomography. The system features high sensitivity to phase gradients and high resolution, requires a low-power sealed x-ray tube, a single optical element, and fits in a small footprint. It is compatible with standard x-ray detector technologies: in our experiments, we have observed that single-photon counting offered higher angular sensitivity, whereas flat panels provided a larger field of view. The system is benchmarked against knownmaterial phantoms, and its potential for soft-tissue three-dimensional imaging is demonstrated on small-animal organs: a piglet esophagus and a rat heart.We believe that the simplicity of the setupwe are proposing, combined with its robustness and sensitivity, will facilitate accessing quantitative x-ray phase-contrast microtomography as a research tool across disciplines, including tissue engineering, materials science, and nondestructive testing in general.
Background: Peripheral arterial disease (PAD) is a common and severe disease with a highly increased cardiovascular morbidity and mortality. Through the circulatory disorder and the linked undersupply of oxygen carriers in the lower limbs, the ongoing decrease of the pain-free walking distance occurs with a significant reduction in patients’ quality of life. Studies including activity monitoring for patients with PAD are rare and digital support to increase activity via mobile health technologies is mainly targeted at patients with cardiovascular disease in general. The special requirement of patients with PAD is the need to reach a certain pain level to improve the pain-free walking distance. Unfortunately, both poor adherence and availability of institutional resources are major problems in patient-centered care.
Objective: The objective of this trackPAD pilot study is to evaluate the feasibility of a mobile phone–based self tracking app to promote physical activity and supervised exercise therapy (SET) in particular. We also aim for a subsequent patient centered adjustment of the app prototype based on the results of the app evaluation and process evaluation.
Methods: This study was designed as a closed user group trial, with assessors blinded, and parallel group study with face-to-face components for assessment with a follow-up of 3 months. Patients with symptomatic PAD (Fontaine stage IIa or IIb) and possession of a mobile phone were eligible. Eligible participants were randomly assigned into study and control group, stratified by their distance covered in the 6-min walk test, using the software TENALEA. Participants randomized to the study group received usual care and the mobile intervention (trackPAD) for the follow-up period of 3 months, whereas participants randomized to the control group received only usual care. TrackPAD records the frequency and duration of training sessions and pain level using manual user input. Clinical outcome data were collected at the baseline and after 3 months via validated tools (6-min walk test, ankle-brachial index, and duplex ultrasound at the lower arteries) and self-reported quality of life. Usability and quality of the app was determined using the user version of the Mobile Application Rating Scale.
Results: The study enrolled 45 participants with symptomatic PAD (44% male). Of these participants, 21 (47%) were randomized to the study group and 24 (53%) were randomized to the control group. The distance walked in the 6-min walk test was comparable in both groups at baseline (study group: mean 368.1m [SD 77.6] vs control group: mean 394.6m [SD 100.6]).
Conclusions: This is the first trial to test a mobile intervention called trackPAD that was designed especially for patients with PAD. Its results will provide important insights in terms of feasibility, effectiveness, and patient preferences of an app-based mobile intervention supporting SET for the conservative treatment of PAD.
Background: Mobile health interventions are intended to support complex health care needs in chronic diseases digitally, but they are mainly targeted at general health improvement and neglect disease-specific requirements. Therefore, we designed TrackPAD, a smartphone app to support supervised exercise training in patients with peripheral arterial disease.
Objective: This pilot study aimed to evaluate changes in the 6-minute walking distance (meters) as a primary outcome measure. The secondary outcome measures included changes in physical activity and assessing the patients’ peripheral arterial disease–related quality of life.
Methods: This was a pilot two-arm, single-blinded, randomized controlled trial. Patients with symptomatic PAD (Fontaine stage IIa/b) and access to smartphones were eligible. Eligible participants were randomly assigned to the study, with the control group stratified by the distance covered in the 6-minute walking test using the TENALEA software. Participants randomized to the intervention group received usual care and the mobile intervention (TrackPAD) for the follow-up period of 3 months, whereas participants randomized to the control group received routine care only. TrackPAD records the frequency and duration of training sessions and pain levels using manual user input. Clinical outcome data were collected at the baseline and after 3 months via validated tools (the 6-minute walk test and self-reported quality of life). The usability and quality of the app were determined using the Mobile Application Rating Scale user version.
Results: The intervention group (n=19) increased their mean 6-minute walking distance (83 meters, SD 72.2), while the control group (n=20) decreased their mean distance after 3 months of follow-up (–38.8 meters, SD 53.7; P=.01). The peripheral arterial disease–related quality of life increased significantly in terms of “symptom perception” and “limitations in physical functioning.” Users’ feedback showed increased motivation and a changed attitude toward performing supervised exercise training.
Conclusions: Besides the rating providing a valuable support tool for the user group, the mobile intervention TrackPAD was linked to a change in prognosis-relevant outcome measures combined with enhanced coping with the disease. The influence of mobile interventions on long-term prognosis must be evaluated in the future.
Highly-sensitive single-step sensing of levodopa by swellable microneedle-mounted nanogap sensors
(2023)
Microneedle (MN) sensing of biomarkers in interstitial fluid (ISF) can overcome the challenges of self-diagnosis of diseases by a patient, such as blood sampling, handling, and measurement analysis. However, the MN sensing technologies still suffer from poor measurement accuracy due to the small amount of target molecules present in ISF, and require multiple steps of ISF extraction, ISF isolation from MN, and measurement with additional equipment. Here, we present a swellable MN-mounted nanogap sensor that can be inserted into the skin tissue, absorb ISF rapidly, and measure biomarkers in situ by amplifying the measurement signals by redox cycling in nanogap electrodes. We demonstrate that the MN-nanogap sensor measures levodopa (LDA), medication for Parkinson disease, down to 100 nM in an aqueous solution, and 1 μM in both the skin-mimicked gelatin phantom and porcine skin.
Long-Term outcome of infantile onset pompe disease patients treated with enzyme replacement therapy
(2024)
Background: Enzyme replacement therapy (ERT) with recombinant human alglucosidase alfa (rhGAA) was approved in Europe in 2006. Nevertheless, data on the long-term outcome of infantile onset Pompe disease (IOPD) patients at school age is still limited.
Objective: We analyzed in detail cardiac, respiratory, motor, and cognitive function of 15 German-speaking patients aged 7 and older who started ERT at a median age of 5 months.
Results: Starting dose was 20 mg/kg biweekly in 12 patients, 20 mg/kg weekly in 2, and 40 mg/kg weekly in one patient. CRIM-status was positive in 13 patients (86.7%) and negative or unknown in one patient each (6.7%). Three patients (20%) received immunomodulation. Median age at last assessment was 9.1 (7.0–19.5) years. At last follow-up 1 patient (6.7%) had mild cardiac hypertrophy, 6 (42.9%) had cardiac arrhythmias, and 7 (46.7%) required assisted ventilation. Seven patients (46.7%) achieved the ability to walk independently and 5 (33.3%) were still ambulatory at last follow-up. Six patients (40%) were able to sit without support, while the remaining 4 (26.7%) were tetraplegic. Eleven patients underwent cognitive testing (Culture Fair Intelligence Test), while 4 were unable to meet the requirements for cognitive testing. Intelligence quotients (IQs) ranged from normal (IQ 117, 102, 96, 94) in 4 patients (36.4%) to mild developmental delay (IQ 81) in one patient (9.1%) to intellectual disability (IQ 69, 63, 61, 3x < 55) in 6 patients (54.5%). White matter abnormalities were present in 10 out of 12 cerebral MRIs from 7 patients.