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In this work, we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip. The diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide grating. Two arrayed waveguide grating designs with 256 channels were tested, which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal measurements. Design 1 supports a bandwidth of 22 nm, with which a sensitivity of up to 91 dB (830 µW) and an axial resolution of 10.7 µm was measured. Design 2 supports a bandwidth of 48 nm, with which a sensitivity of 90 dB (480 µW) and an axial resolution of 6.5 µm was measured. The silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process, which allows their monolithic co-integration on top of an optoelectronic silicon chip. As a benchmark for chip-based optical coherence tomography, tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip gratings. The similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.
With Cloud Computing and multi-core CPUs parallel computing resources are becoming more and more affordable and commonly available. Parallel programming should as well be easily accessible for everyone. Unfortunately, existing frameworks and systems are powerful but often very complex to use for anyone who lacks the knowledge about underlying concepts. This paper introduces a software framework and execution environment whose objective is to provide a system which should be easily usable for everyone who could benefit from parallel computing. Some real-world examples are presented with an explanation of all the steps that are necessary for computing in a parallel and distributed manner.
We present a new concept of 3D polymer-based 1 × 4 beam splitter for wavelength splitting around 1550 nm. The beam splitter consists of IP-Dip polymer as a core and polydimethylsiloxane (PDMS) Sylgard 184 as a cladding. The splitter was designed and simulated with two different photonics tools and the results show high splitting ratio for single-mode and multi-mode operation with low losses. Based on the simulations, a 3D beam splitter was designed and realized using direct laser writing (DLW) process with adaptation to coupling to standard single-mode fiber. With respect to the technological limits, the multi-mode splitter having core of (4 × 4) μm 2 was designed and fabricated together with supporting stable mechanical construction. Splitting properties were investigated by intensity monitoring of splitter outputs using optical microscopy and near-field scanning optical microscopy. In the development phase, the optical performance of fabricated beam splitter was examined by splitting of short visible wavelengths using red light emitting diode. Finally, the splitting of 1550 nm laser light was studied in detail by near-field measurements and compared with the simulated results. The nearly single-mode operation was observed and the shape of propagating mode and mode field diameter was well recognized.
Recently the use of microRNAs (miRNAs) as biomarkers for a multitude of diseases has gained substantial significance for clinical as well as point-of-care diagnostics. Amongst other challenges, however, it holds the central requirement that the concentration of a given miRNA must be evaluated within the context of other factors in order to unambiguously diagnose one specific disease. In terms of the development of diagnostic methods and devices, this implies an inevitable demand for multiplexing in order to be able to gauge the abundance of several components of interest in a patient’s sample in parallel. In this study, we design and implement different multiplexed versions of our electrochemical microfluidic biosensor by dividing its channel into subsections, creating four novel chip designs for the amplification-free and simultaneous quantification of up to eight miRNAs on the CRISPR-Biosensor X (‘X’ highlighting the multiplexing aspect of the device). We then use a one-step model assay followed by amperometric readout in combination with a 2-minute-stop-flow-protocol to explore the fluidic and mechanical characteristics and limitations of the different versions of the device. The sensor showing the best performance, is subsequently used for the Cas13a-powered proof-of-concept measurement of two miRNAs (miRNA-19b and miRNA-20a) from the miRNA-17∼92 cluster, which is dysregulated in the blood of pediatric medulloblastoma patients. Quantification of the latter, alongside simultaneous negative control measurements are accomplished on the same device. We thereby confirm the applicability of our platform to the challenge of amplification-free, parallel detection of multiple nucleic acids.
Im Rahmen eines Forschungsprojektes gingen die Autorinnen folgender Frage nach: Welche identitätsstiftenden Werte der Siebenbürger Sachsen/Sächsinnen sind heute in Oberösterreich noch wahrnehmbar? Es wurde dazu ein qualitatives Forschungsdesign gewählt. Die Ergebnisse zeigen, dass die Auswanderung, Fluchterfahrung und die Ankunft in Österreich wesentlich die Identitäten dieser Personengruppe bestimmte und noch immer beeinflusst. Es wird aufgezeigt, wie sich die Identitäten über drei Generationen verändert haben und was noch als identitätsstiftend erfahrbar ist. Die Ergebnisse leisten einen Beitrag zur Identitätsforschung und bieten eine gute Möglichkeit Erkenntnisse über die beforschte Zielgruppe hinaus zu generieren.
Mobility choices - an instrument for precise automatized travel behavior detection & analysis
(2021)
Im Zuge der Digitalisierung und der stetigen Entwicklung neuer Technologien hat sich die Möglichkeit neuer Geschäftsmodelle eröffnet. Durch den Einsatz dieser Technologien und ihrer Nutzungspotentiale können auch bereits bestehende Geschäftsmodelle revolutioniert werden. Auch die wissensbasierte Dienstleistungsbranche ist diesem Trend ausgesetzt. Da bei der Dienstleistungserstellung keine materiellen Güter erstellt werden, eignet sich diese Branche für eine Transformation hin zu einem digitalen Geschäftsmodell. Fraglich ist, was bei der Konzeption von digitalen Geschäftsmodellen auf Basis wissensbasierter Dienstleistungen zu beachten ist und welche Erfolgsfaktoren diese prägen.
Um diese Frage beantworten zu können, ist eine Literaturrecherche erforderlich. Als Ergänzung wird ein beispielhaftes Forschungsdesign zur Erhebung von Erfolgsfaktoren für digitale Geschäftsmodelle aufgezeigt. Auf den daraus resultierenden Ergebnissen bauen die Übertragung und die kritische Betrachtung auf den zu untersuchenden Gegenstandsbereich der Arbeit auf. Da die Komplexität des Themenbereichs ein Basisfachwissen voraussetzt, ist die Zielgruppe durch dieses Faktum definiert.
Zu Beginn werden die Begrifflichkeiten sowie die zugehörigen Theorien diskutiert. Basierend auf der Diskussion der Begrifflichkeiten und zugehörigen Theorien werden die Konzeptionsmöglichkeiten digitaler Geschäftsmodelle sowie Besonderheiten bei der Konzeption von wissensbasierten Dienstleistungen untersucht. Zusätzlich wird die Herangehensweise in Bezug auf das Change-Management, die Methoden und die Werkzeuge genauer betrachtet. Ersichtlich wird, dass die aktive Mitarbeiterbeteiligung sowie die Zeit kritische Themen sind. Ebenfalls von besonderer Bedeutung ist der Fokus auf die Kundenakzeptanz und Kundenintegration, um weitere Funktionen in eine passende Richtung aufzubauen.
Die von Krebs, Hepp und Hadwich (2017) identifizierten 30 Erfolgsfaktoren für die Integration wissensintensiver Unternehmensdienstleistungen im Rahmen des so genannten dienstleistungsorientierten Geschäftsmodells der Servicetransformation werden diskutiert und in Bezug zu digitalen Geschäftsmodellen auf Basis wissensbasierter Dienstleistungen genauer betrachtet und angepasst.
Das Ergebnis sind 26 Erfolgsfaktoren, denn die Faktoren „Erfahrene Führungskraft von extern“, „Überprüfung und Anpassung der bestehenden Prozesse und Sicherstellung einer prozessbezogenen Verbindung zwischen dem neuen Geschäftsbereich und den ursprünglichen Bereichen“, „Produktbezug der Dienstleistung“ und „Neue Vertriebsstruktur und Abstimmung der Kundenansprache“ sind nicht relevant für den zu untersuchenden Gegenstandsbereich. Sie beziehen sich stark auf die Integration eines weiteren Geschäftsbereichs in ein produzierendes Unternehmen.
Die folgenden fünf Erfolgsfaktoren wurden passend für den Gegenstandsbereich abgeändert: „Änderung des Führungsstils“ zu „Führungsstil mit toleranter Fehlerkultur“, „Aktive Kommunikation“ zu „Aktive Kommunikation des Servicegedankens“, „Verwendung der Kundendaten aus dem Vertrieb und der Verwendung von Produkten“ zu „Verwendung der Kundendaten aus dem Vertrieb von Dienstleistungen“, „Nutzung des Ansehens des Produktgeschäfts für das Dienstleistungsgeschäft und Steigerung des Bekanntheitsgrades durch Marketingaktivitäten“ zu „Ansehen und Bekanntheitsgrad des Dienstleistungsgeschäfts“, „Strukturen für den Austausch zwischen Produkt- und Dienstleitungsbereich“ zu „Strukturen für den Austausch zwischen den Dienstleistungsteams“
Der Fokus wird mit Hilfe der Anpassungen von der Integration eines weiteren Geschäftsbereichs auf ein eigenständiges digitales Geschäftsmodell auf Basis wissensbasierter Dienstleistungen gelenkt. Die restlichen 21 Erfolgsfaktoren wurden ohne Änderung übernommen.
Die Ergebnisse dieser Arbeit bilden ein gutes Fundament zur weiteren Betrachtung des Untersuchungsgegenstands. Darauf aufbauend ist eine qualitative Studie in Form von weiteren Experteninterviews denkbar. Aus der Kombination der Ergebnisse aus den Interviews und dieser Arbeit wird die Erstellung eines Fragebogens für eine quantitative Umfrage möglich.
Durch die voranschreitende Digitalisierung der Produktion ergeben sich zunehmend neue Möglichkeiten. Eine dieser Möglichkeiten ist der Einsatz von Process Mining. Mit Process Mining können Daten einem Prozess zugeordnet werden, um diesen zu visualisieren und zu untersuchen. Dadurch ist es möglich, Prozesse real zu entdecken, zu überwachen und zu verbessern. Die vorliegende Masterarbeit untersucht, unter welchen Rahmenbedingungen Process-Mining bei modular aufgebauten Montagesystemen in der Massenfertigung einen Mehrwert bieten kann. Durch eine ausführliche Literaturanalyse und dem praktischen Versuch mittels eines Experiments wird darauf eine Antwort gegeben.
Die vorliegende Arbeit beschreibt eine Methode zur Prognose von Anomalien in einzelnen Sensordaten für die Anwendung in Expertensystemen im Bereich der Biomassekraftwerke. Die in fünf Schritten beschriebene Methode beinhaltet neben der Datenaufbereitung eine Anomalievorauswahl durch eine unüberwachte Ausreißererkennung, welche mittels des PYOD-Toolkit umgesetzt wurde. Bei der anschließenden Anomaliebestimmung wird der zuvor generierte binäre Zielvektor durch einen mit dem System vertrauten Experten validiert. Eine darauffolgende überwachte binäre Klassifikation mit unbekannten Betriebsdaten ergibt, dass mittel- bis langfristige Anomalien im Mehrstunden- bis Mehrtagesbereich in Form eines Trends reproduktiv vorhergesagt werden können. Kurzfristige Anomalien im Minutenbereich in Form von Extremfällen können hingegen nicht reproduktiv vorhergesagt werden. Eine zusätzliche Untersuchung zur Vorhersage einer Anomalie noch vor deren tatsächlichen Eintrittszeitpunkt brachte keine zufriedenstellenden Ergebnisse. Demnach lässt sich mit dieser Methode nur eine bestimmte Art von Anomalien in Expertensystemen für Biomassekraftwerke vorhersagen. Dazu sollte zudem darauf geachtet werden, dass es trotz positiv erzielter quantitativer Ergebnisse notwendig ist, für die qualitative Prüfung einen mit dem System vertrauten Experten hinzuzuziehen und dass für die zu prognostizierende Anomalie die geeignete Abtastzeit zu wählen ist. Abschließend bleibt zu erwähnen, dass Anomalien, welche nur durch Über- bzw. Unterschreitung eines definierten Grenzwertes gekennzeichnet werden, als zu trivial für diese Methode gelten. Diese können über eine einfache Grenzwertbetrachtung identifiziert werden.