Bibliographie 2021
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- 2021 (26)
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Im Rahmen eines Forschungsprojektes gingen die Autorinnen folgender Frage nach: Welche identitätsstiftenden Werte der Siebenbürger Sachsen/Sächsinnen sind heute in Oberösterreich noch wahrnehmbar? Es wurde dazu ein qualitatives Forschungsdesign gewählt. Die Ergebnisse zeigen, dass die Auswanderung, Fluchterfahrung und die Ankunft in Österreich wesentlich die Identitäten dieser Personengruppe bestimmte und noch immer beeinflusst. Es wird aufgezeigt, wie sich die Identitäten über drei Generationen verändert haben und was noch als identitätsstiftend erfahrbar ist. Die Ergebnisse leisten einen Beitrag zur Identitätsforschung und bieten eine gute Möglichkeit Erkenntnisse über die beforschte Zielgruppe hinaus zu generieren.
Recently the use of microRNAs (miRNAs) as biomarkers for a multitude of diseases has gained substantial significance for clinical as well as point-of-care diagnostics. Amongst other challenges, however, it holds the central requirement that the concentration of a given miRNA must be evaluated within the context of other factors in order to unambiguously diagnose one specific disease. In terms of the development of diagnostic methods and devices, this implies an inevitable demand for multiplexing in order to be able to gauge the abundance of several components of interest in a patient’s sample in parallel. In this study, we design and implement different multiplexed versions of our electrochemical microfluidic biosensor by dividing its channel into subsections, creating four novel chip designs for the amplification-free and simultaneous quantification of up to eight miRNAs on the CRISPR-Biosensor X (‘X’ highlighting the multiplexing aspect of the device). We then use a one-step model assay followed by amperometric readout in combination with a 2-minute-stop-flow-protocol to explore the fluidic and mechanical characteristics and limitations of the different versions of the device. The sensor showing the best performance, is subsequently used for the Cas13a-powered proof-of-concept measurement of two miRNAs (miRNA-19b and miRNA-20a) from the miRNA-17∼92 cluster, which is dysregulated in the blood of pediatric medulloblastoma patients. Quantification of the latter, alongside simultaneous negative control measurements are accomplished on the same device. We thereby confirm the applicability of our platform to the challenge of amplification-free, parallel detection of multiple nucleic acids.
With Cloud Computing and multi-core CPUs parallel computing resources are becoming more and more affordable and commonly available. Parallel programming should as well be easily accessible for everyone. Unfortunately, existing frameworks and systems are powerful but often very complex to use for anyone who lacks the knowledge about underlying concepts. This paper introduces a software framework and execution environment whose objective is to provide a system which should be easily usable for everyone who could benefit from parallel computing. Some real-world examples are presented with an explanation of all the steps that are necessary for computing in a parallel and distributed manner.
In this work, we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip. The diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide grating. Two arrayed waveguide grating designs with 256 channels were tested, which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal measurements. Design 1 supports a bandwidth of 22 nm, with which a sensitivity of up to 91 dB (830 µW) and an axial resolution of 10.7 µm was measured. Design 2 supports a bandwidth of 48 nm, with which a sensitivity of 90 dB (480 µW) and an axial resolution of 6.5 µm was measured. The silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process, which allows their monolithic co-integration on top of an optoelectronic silicon chip. As a benchmark for chip-based optical coherence tomography, tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip gratings. The similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.
Mobility choices - an instrument for precise automatized travel behavior detection & analysis
(2021)
Der erste Band der ogsa-Reihe greift aktuelle Themen der Sozialen Arbeit in der Postmigrationsgesellschaft auf. Dazu werden mit Migration verbundene Phänomene in ihren theoretischen Grundannahmen, institutionellen Strukturen und in Praxisfeldern reflektiert sowie kritische Perspektiven auf einen professionellen Umgang damit entwickelt. In Tandems aus Theorie und Praxis werden jeweils Themen wie Differenz und Macht, Rassismus, Postkolonialität, Intersektionalität, Empowerment, Social Justice, Border Struggles, Critical Citizenship u. v. m. diskutiert.
Ordnung aus der Mitte
(2021)
