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International Entrepreneurship explains the opportunities and challenges facing internationalizing entrepreneurial ventures. The book inlcudes a thorough discussion of fundamentals as well as contemporary research findings. Numerous cases, featuring diverse contexts, illustrate theory and help classroom use.
Pooled data from published reports on infants with clinically diagnosed vitamin B12 (B12) deficiency were analyzed with the purpose of describing the presentation, diagnostic approaches, and risk factors for the condition to inform prevention strategies. An electronic (PubMed database) and manual literature search following the PRISMA approach was conducted (preregistration with the Open Science Framework, accessed on 15 February 2023). Data were described and analyzed using correlation analyses, Chi-square tests, ANOVAs, and regression analyses, and 102 publications (292 cases) were analyzed. The mean age at first symptoms (anemia, various neurological symptoms) was four months; the mean time to diagnosis was 2.6 months. Maternal B12 at diagnosis, exclusive breastfeeding, and a maternal diet low in B12 predicted infant B12, methylmalonic acid, and total homocysteine. Infant B12 deficiency is still not easily diagnosed. Methylmalonic acid and total homocysteine are useful diagnostic parameters in addition to B12 levels. Since maternal B12 status predicts infant B12 status, it would probably be advantageous to target women in early pregnancy or even preconceptionally to prevent infant B12 deficiency, rather than to rely on newborn screening that often does not reliably identify high-risk children.
Redundanz und Varietät
(2023)
Ausrechnen oder aushandeln?
(2023)
Das Kreisgespräch
(2023)
Formen des Dialogs
(2023)
Die persönliche Black-Box
(2023)
Der Schlüssel zur Zukunft
(2023)
Digital twin as enabler of business model innovation for infrastructure construction projects
(2023)
Emerging technologies and methods are becoming an important element of the construction industry. Digital Twins are used as a base to store data in BIM models and make use out of the data respectively make the data visible. The transparency in all phases of the lifecycle of building and infrastructure assets is crucial in order to get a more efficient lifecycle of planning, construction and maintenance. Whereas other industries increased performance in these phases by making use out of the data, construction industry is stuck in traditional methods and business models. In this paper we propose a concept that focuses on the digital production twin. The comparison of planning data with As-Is production data can empower a data driven continuous improvement process and support the decision making process of future innovations and suitable business models. This paper outlines the possibility to use the data stored in a digital twin with regards to the evaluation of possible business models.
Through mandatory ESG (environmental, social, governance) reporting large companies must disclose their ESG activities showing how sustainability risks are incorporated in their decision-making and production processes. This disclosure obligation, however, does not apply to small and medium-sized enterprises (SME), creating a gap in the ESG dataset. Banks are therefore required to collect sustainability data of their SME customers independently to ensure complete ESG integration in the risk analysis process for loans. In this paper, we examine ESG risk analysis through a smart science approach laying the focus on possible value outcomes of sustainable smart services for banks as well as for their (SME) customers. The paper describes ESG factors, how services can be derived from them, targeted metrics of ESG and an ESG Service Creation Framework (business ecosystem building, process model, and value creation). The description of an exemplary use case highlighting the necessary ecosystem for service creation as well as the created value concludes the paper.
Background: Cardiovascular disease is the major cause of death worldwide. Although knowledge regarding diagnosing and treating cardiovascular disease has increased dramatically, secondary prevention remains insufficiently implemented due to failure among affected individuals to adhere to guideline recommendations. This has continued to lead to high morbidity and mortality rates. Involving patients in their healthcare and facilitating their active roles in their chronic disease management is an opportunity to meet the needs of the increasing number of cardio-vascular patients. However, simple recall of advice regarding a more preventive lifestyle does not affect sustainable behavioral lifestyle changes. We investigate the effect of plaque visualization combined with low-threshold daily lifestyle tasks using the smartphone app PreventiPlaque to evaluate change in cardiovascular risk profile. Methods: and study design: This randomized, controlled clinical trial includes 240 participants with ultrasound evidence of atherosclerotic plaque in one or both carotid arteries, defined as focal thickening of the vessel wall measuring 50% more than the regular vessel wall. A criterion for participation is access to a smartphone suitable for app usage. The participants are randomly assigned to an intervention or a control group. While both groups receive the standard of care, the intervention group has additional access to the PreventiPlaque app during the 12-month follow-up. The app includes daily tasks that promote a healthier lifestyle in the areas of smoking cessation, medication adherence, physical activity, and diet. The impact of plaque visualization and app use on the change in cardiovascular risk profile is assessed by SCORE2. Feasibility and effectiveness of the PreventiPlaque app are evaluated using standardized and validated measures for patient feedback.
Immersive educational spaces
(2023)
"If only we had had such opportunities to grasp history like this when I was young" – words by an almost 80-year-old woman holding an iPad on which both, the buildings in the background and a tower in the form of a virtual 3D object, appear within reach. To "grasp" history - what an apt use of this action-oriented word for an augmented reality application built on considerations of thinking and acting in history. This telling image emerged during the first test run of the app i.appear which will be the focus of this article's considerations on the use of immersive learning environments. The application i.appear has been used in the city of Dornbirn (Austria) for a year now to teach historical content through location-based augmented reality and other interactive and multimedia technologies. After a brief description of the potential of such applications, the epistemological structure of the hosting app i.appear and its functionality will be outlined. This article will focus on the “Baroque Master Builders” tour of the hosting app that was created and tested as part of the current research.
In this paper, a 256-channel, 10-GHz arrayed waveguide gratings demultiplexer for ultra-dense wavelength division multiplexing was designed using an in-house developed tool called AWG-Parameters. The AWG demultiplexer was designed for a central wavelength of 1550 nm and the structure was simulated in PHASAR tool from Optiwave. Two different AWG designs were developed and the influence of the design parameters on the AWG performance was studied.
We present design of planar 16-channel, 100-GHz multi-mode polymer-based AWG. This AWG was designed for central wavelength of 1550 nm applying AWG-Parameters tool. The AWG structure was created and simulated in the commercial photonic tool PHASAR from Optiwave. Achieved transmission characteristics were evaluated by AWG-Analyzer tool. For the design, multi-mode waveguides having a cross-section of (4x4) µm2 were used. The simulated results show strong worsening of the transmission characteristics in comparison when using single-mode waveguides. Nevertheless, the transmitting channels are clearly separated. The reason for using thicker multi-mode waveguides in the design is possibility to fabricate the AWG structure on polymer basis using direct laser writing lithography.
This paper presents design, simulation, and optimization of the three-dimensional 1×4 optical multimode interference splitter using IP-Dip polymer as a core and polydimethylsiloxane (PDMS) Sylgard 184 as a cladding. The splitter was simulated by using beam propagation method in BeamPROP simulation engine of RSoft photonic tool and optimized for an operating wavelength of 1.55 µm. According to the minimum insertion loss, the dimensions of the MMI coupler and the length of the whole MMI splitter structure were optimized applying a waveguide with a core size of 4×4 µm2. The objective of the study is to create a design for fabrication by three-dimensional direct laser writing optical lithography.
Design, simulation, and optimization of the 1×4 optical three-dimensional multimode interference splitter using IP-Dip polymer as a core and polydimethylsiloxane (PDMS) Sylgard 184 as a cladding is demonstrated. The splitter was simulated by using beam propagation method in BeamPROP simulation module of RSoft photonic tool and optimized for an operating wavelength of 1.55 μm . According to the minimum insertion loss, the dimensions of the splitter were optimized for a waveguide with a core size of 4×4 μm2 . The objective of the study is to create the design for fabrication by three-dimensional direct laser writing optical lithography.
Grey Box models provide an important approach for control analysis in the Heating, Ventilation and Air Conditioning (HVAC) sector. Grey Box models consist of physical models where parameters are estimated from data. Due to the vast amount of component models that can be found in literature, the question arises, which component models perform best on a given system or dataset? This question is investigated systematically using a test case system with real operational data. The test case system consists of a HVAC system containing an energy recovery unit (ER), a heating coil (HC) and a cooling coil (CC). For each component, several suitable model variants from the literature are adapted appropriately and implemented. Four model variants are implemented for the ER and five model variants each for the HC and CC. Further, three global optimization algorithms and four local optimization algorithms to solve the nonlinear least squares system identification are implemented, leading to a total of 700 combinations. The comparison of all variants shows that the global optimization algorithms do not provide significantly better solutions. Their runtimes are significantly higher. Analysis of the models shows a dependency of the model accuracy on the number of total parameters.
A model is presented that allows for the calculation of the success probability by which a vanilla Evolution Strategy converges to the global optimizer of the Rastrigin test function. As a result a population size scaling formula will be derived that allows for an estimation of the population size needed to ensure a high convergence security depending on the search space dimensionality.