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Optoelectronic system based on photonic integrated circuits to miniaturize spectral domain OCT
(2023)
We present a miniaturized optical coherence tomography (OCT) setup based on photonic integrated circuits (PIC) for the 850 nm range. We designed a 512-channel arrayed waveguide grating (AWG) on a PIC for spectral domain OCT (SD-OCT) that is co-integrated with PIN-photodiodes and analog-to-digital-converters on one single chip. This image sensor is combined with all the necessary electronics to act as a camera. It is integrated into a fiber-based OCT system, achieving a sensitivity of >80dB and various samples are imaged. This optoelectronic system will allow building small and cost-effective OCT systems to monitor retinal diseases.
Coupling is one of the most frequently mentioned metric in software systems. However, to measure logical coupling between microservices, runtime information is needed or the availability of service-log files to analyze the calls between services is required. This work presents our emerging results, in which we propose a metric to statically calculate logical coupling between microservices based on commits to versioning systems. We performed an initial validation of the proposed metric with a dataset containing 145 open-source microservices projects. The results illustrate how logical coupling affects every system and increases overtime. However, we did not find a correlation between the number of commits or the number of developers and the introduction of logical coupling. In future, we investigate why, how, and when logical coupling is introduced in a system.
Signatures of the optical stark effect on entangled photon pairs from resonantly-pumped quantum dots
(2023)
Two-photon resonant excitation of the biexciton-exciton cascade in a quantum dot generates highly polarization-entangled photon pairs in a near-deterministic way. However, the ultimate level of achievable entanglement is still debated. Here, we observe the impact of the laser-induced ac-Stark effect on the quantum dot emission spectra and on entanglement. For increasing pulse-duration-to-lifetime ratios and pump powers, decreasing values of concurrence are recorded. Nonetheless, additional contributions are still required to fully account for the observed below-unity concurrence.
Hot water heat pumps are well suited for demand side management, as the heat pump market faced a rapid growth in the past years with the trend to decentralized domestic hot water use. Sales were accelerated through wants and needs of energy conservation, energy efficiency, and less restrictive rules regarding Legionella. While in literature the model predictive control potential for heat pumps is commonly shown in simulations, the share of experimental studies is relatively low. To this day, experimental studies considering solely domestic hot water use are not available. In this paper, the realistic achievable model predictive control potential of a hot water heat pump is compared to the standard hysteresis control, to provide an experimental proof. We show for the first time, how state-of-the-art approaches (model predictive control, system identification, live state estimation, and demand prediction) can be transferred from electric hot water heaters to hot water heat pumps, combined, and implemented into a real-world hot water heat pump setup. The optimization approach, embedded in a realistic experimental setting, leads to a decrease in electric energy demand and cost per unit electricity by approximately 12% and 14%, respectively. Further, an increase in efficiency by approximately 13% has been achieved.
Activation of heat pump flexibilities is a viable solution to support balancing the grid via Demand Side Management measures and fulfill the need for flexibility options. Aggregators as interface between prosumers, distribution system operators and balance responsible parties face the challenge due to data privacy and technical restrictions to transform prosumer information into aggregated available flexibility to enable trading thereof. Thereby, literature lacks a generic, applicable and widely accepted flexibility estimation method for heat pumps,which incorporates reduced sensor and system information, system- and demand-dependent behaviour. In this paper, we adapt and extend a method from literature, by incorporating domain knowledge to overcome reduced sensor and system information. We apply data of five real-world heat pump systems, distinguish operation modes, estimate power and energy flexibility of each single heat pump system, proof transferability of the method, and aggregate the flexibilities available to showcase a small HP pool as a proof of concept.
The presented master thesis of the study subject International Management and Leadership at the University of Applied Science Vorarlberg in Dornbirn handles the potential future influence of the EU Corporate Sustainability Due diligence on SMEs. First this thesis introduces the most important regulations that might come into place with this Due Diligence Act and gives a theoretical input when and how it will come into place, and also who it will affect directly and who will be affected indirectly. The empirical data resulted of several qualitative expert interviews and a following quantitative research. The expert interviews are split in two different groups, first the topic experts from institutions like chamber of commerce or chamber of labour and second experts from highly successful Austrian companies which are already handling the topic and the future challenges. Expected outcome of the qualitative interviews was a better view on the actual situation especially the impact on small and medium enterprises. On the basis of this results the quantitative survey was produced. In the quantitative survey the goal was to see, how much entrepreneurs and companies in the small and medium sector already are aware of the upcoming legal challenges throughout the supply chain. With all this collected data the practical outcome of this thesis is the Checklist, which helps entrepreneurs to find out if and how much they will be affected by the Act. And finally, the most important part is the Guideline, which introduces first risk assessment tools, that will help companies to prepare for future legislation and bring undoubtedly a certain advantage for the upcoming challenges.
The Fast Average Current Mode control methodology is a novel method for the implementation of a current compensator in a switched-mode power supply. It does not require compensation against sub-harmonic instability and is inductor independent. In this work, the digital implementation of this topology is compared against an analog implementation using simulation. Additionally, a hardware prototype is created to validate the digital simulation's results. In a Simulink environment, parameters of the digital implementation, such as the digital-to-analog converter resolutions and the delay counter frequency are varied to research their impact on system performance. The simulations show that a digital current compensator has similar performance as an analog implementation when designed tailored to the application. When evaluating the whole control loop the digital system is inferior due to added delays caused by digital to analog conversion. By operating the Buck converter hardware implementation as a current source, the functionality of the current mode control implementation in a FPGA was proven. Voltage control cannot be validated due to hardware issues. Due to the successful simulation of the source code with a mixed signal model of the converter, it can be assumed that it is functional. Apart from performance, a digital implementation shows many benefits compared to an analog solution, such as configurability of control parameters and easy compensation of component variations and aging.
The main aims of this work are the validation of the developed process of gluing a single-mode optical fiber array with a photonic chip and the selection of a more suitable adhesive from the two adhesives being compared. An active alignment system was used for adjusting the two optical fiber arrays to a photonics chip. The gluing was done by two compared UV curable adhesives applied in the optical path. The insertion losses of glued coupling were measured and investigated at two discrete wavelengths 1310 nm and 1550 nm during temperature testing in the climatic chamber according to Telcordia GR_1209_Corei04 [3]. The measurement, investigation, and comparison of insertion losses of the glued coupling at the spectral band from 1530 nm to 1570 nm were done immediately after gluing process and after three temperature cycles in the climatic chamber with one month delay.
Scrum has been a prominent project management framework for managing software development projects. The scrum team embodies values such as commitment, focus, respect, courage, and openness to develop trust, which serves as the foundation of the scrum framework. However, in recent years, scrum teams are shifting towards a work-from-home environment which is relatively new to most of them and known to present various challenges. Looking at the benefits of adhering to scrum values, this study aims to investigate the challenges scrum teams experience in adhering to scrum values while operating virtually, as well as to explore practical strategies to overcome the identified challenges, particularly during the storming stage of team development. This research employed a qualitative methodology using semi-structured interviews with scrum team members who have experience working in a virtual environment. Through qualitative content analysis of semi-structured interviews, this research identifies significant challenges within five main categories: communication, collaboration, interpersonal dynamics, the virtual work environment, and personal workspace issues. However, beyond the challenges, the study reveals practical strategies as well for successful team dynamics and higher efficiency. The strategies derived from team members' experiences are categorized into six categories: enhanced meeting management, leveraging in-person engagements, optimizing tools & technology, effective communication strategies, team-building, and nurturing a positive work culture.
In this work, parametric excitation is introduced in a fully balanced flexible rotor mounted on two identical active gas foil bearings. The active gas foil bearings change the top foil shape harmonically with a specific amplitude and frequency. The deformable foil shape is approximated by an analytical function, while the gas pressure distribution is evaluated by the numerical solution of the Reynolds equation for compressible flow. The harmonic variation of the foil shape generates a respective variation in the bearings’ stiffness and damping properties and the system experiences parametric resonances and antiresonances in specific excitation frequencies. The nonlinear gas bearing forces generate bifurcations in the solutions of the system at certain rotating speeds and excitation frequencies; period doubling and Neimark-Sacker bifurcations are noticed in the examined system, and their progress is evaluated as the two bifurcation parameters (rotating speed and parametric excitation frequency) are changed, though a codimension-2 numerical continuation of limit cycles. It is found that at specific range of excitation frequency there are parametric anti-resonances and the bifurcations collide and vanish. Therefore, a bifurcation-free operating range is established and the system can operate stable at a wide speed range.
The role of entrepreneurs and intrapreneurs in the current zeitgeist is to drive innovation, re-shape rigid, established processes in business as well as for consumers. They use new viewpoints to pioneer new (business) models which focus on ‘smartness’ rather than the purely monetary and short-sighted models of yesteryear. Fostering and supporting the culture of this current zeitgeist is a mayor challenge for entre- and intrapreneurial support infrastructures, namely startup centres and innovation hubs of universities and other public institutions as well as innovation centres of private companies. Hereby, support may range from access to funding over provision of resources such as offices or computing hardware to coaching in the development of business ideas and strategic roadmaps for product and service deployment. In this paper, we focus on describing the status-quo of afore- mentioned support infrastructures in Vorarlberg and the Lake Constance region, then extend the scope to existing (international) approaches for aiding founders and inno- vators in the development of smart services. An analysis of success stories of the Vorarlberg startup centre ‘startupstube’ and other initiatives including their compar- ison to international counterparts builds the basis for a methodological framework for (service science) coaching in entre- and intrapreneurial support infrastructures. The paper is concluded by the description of a framework for choosing the right methods and tools to create service value in entre-/intrapreneurship based upon tested, proven know-how and for defining support infrastructure needs based upon pre-defined stakeholder and target groups as well as the (industry) sectors of the innovators.
Whether at the intramolecular or cellular scale in organisms, cell-cell adhesion adapt to external mechanical cues arising from the static environment of cells and from dynamic interactions between neighboring cells. Cell-cell adhesions need to resist detachment forces to secure the integrity and internal organization of organisms. In the past, various techniques have been developed to characterize adhesion properties of molecules and cells in vitro, and to understand how cells sense and probe their environment. Atomic force microscopy and dual-pipette aspiration, where cells are mainly present in suspension, are common methods for studying detachment forces of cell-cell adhesions. How cell-cell adhesion forces are developed for adherent and environment-adapted cells, however, is less clear. Here, we designed the Cell-Cell Separation Device (CC-SD), a microstructured substrate that measures both intercellular forces and external stresses of cells towards the matrix. The design is based on micropillar arrays originally designed for cell traction-force measurements. We designed PDMS micropillar-blocks, to which cells could adhere and be able to connect to each other across the gap. Controlled stretching of the whole substrate changed the distance between blocks and increased gap size. That allowed us to apply strains to cell-cell contacts, eventually leading to cell-cell adhesion detachment, which was measured by pillar deflections. The CC-SD provided an increase of the gap between the blocks of up to 2.4-fold, which was sufficient to separate substrate-attached cells with fully developed F-actin network. Simultaneously measured pillar deflections allowed us to address cellular response to the intercellular strain applied. The CC-SD thus opens up possibilities for the analysis of intercellular force detachments and sheds light on the robustness of cell-cell adhesions in dynamic processes in tissue development.
Vast amounts of oily wastewater are byproducts of the petrochemical and the shipping industry and to this day frequently discharged into water bodies either without or after insufficient treatment. To alleviate the resulting pollution, water treatment processes are in great demand. Bubble column humidifiers (BCHs) as part of humidification–dehumidification systems are predestined for such a task, since they are insensitive to different feed liquids, simple in design and have low maintenance requirements. While humidification in a bubble column has been investigated plentiful for desalination, a systematic investigation of oily wastewater treatment is missing in literature. We filled this gap by analyzing the treatment of an oil–water emulsion experimentally to derive recommendations for future design and operation of BCHs. Our humidity measurements indicate that the air stream is always saturated after humidification for a liquid height of only 10 cm. A residual water mass fraction of 3.5 wt% is measured after a batch run of six hours. Furthermore, continuous measurements show that an increase in oil mass fraction leads to a decrease in system productivity especially for high oil mass fractions. This decrease is caused by the heterogeneity of the liquid temperature profile. A lower liquid height mitigates this heterogeneity, therefore decreasing the heat demand and improving the overall efficiency. The oil content of the produced condensate is below 15 ppm, allowing discharge into various water bodies. The results of our systematic investigation prove suitability and indicate a strong future potential for the use of BCHs in oily wastewater treatment.
A step change is needed in the deployment of renewable energy if the triple challenge of ensuring climate change mitigation, energy security, and energy affordability is to be met. Yet, social acceptance of infrastructure projects and policies remains a key concern. While there has been decades of fruitful research on the social acceptance of wind energy and other renewables, much of the extant research is cross-sectional in nature, failing to capture the important dynamic processes that can make or break renewable energy projects. This paper introduces a Special Issue of Energy Policy which focuses on the neglected topic of the dynamics of social acceptance of renewable energy, drawing on contributions made at an international research conference held in St. Gallen (Switzerland) in June 2022. In addition to introducing these papers and drawing out common themes, we also seek to offer some conceptual clarity on the issue of dynamics in social acceptance, taking into account the influence of time, power, and scale in shaping decision-making processes. We conclude by highlighting a number of avenues of potential future research.
Lack of transparency and traceability of products and their raw materials means that most products can only be thrown away or not properly recycled due to a lack of relevant data. This conflicts with the circular economy principles, which are demanded by several initiatives, including the European Union. The aim of this master thesis is to analyze this conflict and to propose a technical solution based on Distributed Ledger Technology that enables transparency and traceability of products and their materials. Therefore, the thesis addresses two central research questions: 1. How can traceability and transparency be enabled by integrating a DLT solution? 2. How would a prototype with the integration of smart contracts and DLT look like? To answer these questions, a blockchain solution is implemented using Hyperledger Fabric. The solution uses the immutability and decentralized nature of DLT to record and track the movement of products and their materials throughout their life cycle in the Circular Economy. Furthermore, with private data collections, confidentiality, and privacy are granted while ensuring transparency. The thesis contributes to the Circular Economy field by exploring the principles, models, and challenges of the Circular Economy and the circularity goals of a Digital Product Passport to develop a suitable technical solution. The chosen blockchain framework, Hyperledger Fabric, is presented, and its key components and features are highlighted. The thesis also delves into the design decisions and considerations behind the Digital Product Passport platform, explaining the architecture and transaction flow together with the prototype implementation and demonstration to showcase the functionality of the solution. Results and analysis provide insights into the challenges of the Circular Economy, sustainable resource management, and the Digital Product Passport, resulting in recommendations for future improvements and enhancements. Overall, this thesis offers a practical solution utilizing DLT to enable transparency and traceability in the Circular Economy, contributing to the realization of sustainable and efficient resource management practices to ultimately contribute to the set Circular Economy initiatives.
Recent years have been commanded by a cascade of unpredictable incidents, that have redefined new standards in our private, but also in our professional life. Events like the financial crisis, the COVID-19 pandemic, the energy crisis in Europe, resource scarcity and so forth have caused instability, forcing companies towards flexibility, constantly adapting their operative structures according to the needs of the moment. The effective adaptation to this environment is the key for reacting the dynamism of the market, and for guaranteeing future success. However, the introduction of these crucial changes on a stable company organisation is challenging. Furthermore, due to digitalisation, boundaries between countries have been removed, and the daily cooperation with co-workers and customers all around the globe became the new standard. The establishment of a good corporate culture where diverse people can work in harmony and, is a difficulty that comes ahead.
This master thesis developed from a professional perspective. The topics of change management and corporate culture where combined, and the relationship between these two concepts was studied. This master thesis aims utilising corporate culture as an instrument in managements favour, to implement strategical changes easily and successfully in a more efficient way. The relation between corporate culture and the resistance to change, focusing on the initiation of the change process, was the main area of study. Research questions and hypothesis, formulated with a solid theoretical background, are to be answered based firstly on literature, and secondly on the results of empirical quantitative re-search. To conclude, a set of recommendations for corporates were suggested with the intention of guiding companies how to use corporate culture as an instrument for change management.
Organic acidurias (OAs), urea-cycle disorders (UCDs), and maple syrup urine disease (MSUD) belong to the category of intoxication-type inborn errors of metabolism (IT-IEM). Liver transplantation (LTx) is increasingly utilized in IT-IEM. However, its impact has been mainly focused on clinical outcome measures and rarely on health-related quality of life (HRQoL). Aim of the study was to investigate the impact of LTx on HrQoL in IT-IEMs. This single center prospective study involved 32 patients (15 OA, 11 UCD, 6 MSUD; median age at LTx 3.0 years, range 0.8–26.0). HRQoL was assessed pre/post transplantation by PedsQL-General Module 4.0 and by MetabQoL 1.0, a specifically designed tool for IT-IEM. PedsQL highlighted significant post-LTx improvements in total and physical functioning in both patients' and parents' scores. According to age at transplantation (≤3 vs. >3 years), younger patients showed higher post-LTx scores on Physical (p = 0.03), Social (p < 0.001), and Total (p =0.007) functioning. MetabQoL confirmed significant post-LTx changes in Total and Physical functioning in both patients and parents scores (p ≤ 0.009). Differently from PedsQL, MetabQoL Mental (patients p = 0.013, parents p = 0.03) and Social scores (patients p = 0.02, parents p = 0.012) were significantly higher post-LTx. Significant improvements (p = 0.001–0.04) were also detected both in self- and proxy-reports for almost all MetabQoL subscales. This study shows the importance of assessing the impact of transplantation on HrQoL, a meaningful outcome reflecting patients' wellbeing. LTx is associated with significant improvements of HrQol in both self- and parentreports. The comparison between PedsQL-GM and MetabQoL highlighted that MetabQoL demonstrated higher sensitivity in the assessment of diseasespecific domains than the generic PedsQL tool.
The implementation of direct-to-consumer (D2C) business models has become more important for companies trying to develop a competitive edge and improve consumer engagement in today's rapidly expanding e-commerce market. This master's thesis investigates the important success elements and problems of deploying D2C models in the e-commerce business. The research question focuses on identifying the factors that contribute to the successful transition to D2C models and the obstacles businesses encounter along the way. Through qualitative research using the Eisenhardt method and in-depth case studies with industry experts, this study provides valuable insights into key success factors for direct-to-consumer (D2C) business models in e-commerce.The findings highlight that businesses that effectively implement D2C models utilize key success factors such as a clear value proposition, customer engagement and relationship build- ing, seamless online experiences, targeted marketing and digital advertising, brand identity and storytelling, and flexibility and adaptability. However, they also face challenges related to operational adjustments, marketing and branding investments, competition, and market saturation. Based on these research outcomes, this thesis provides recommendations for businesses seeking to switch to or implement D2C models in e-commerce. These recommendations emphasize embracing a customer-centric mindset, developing digital capabilities, foster- ing strong leadership commitment, leveraging data and analytics, establishing direct customer relationships, optimizing operational processes, building brand trust and credibility, and allocating resources wisely. This master's thesis provides a comprehensive analysis of the key success factors and challenges associated with the transition to or implementation of D2C business models in the e-commerce industry. It provides advice to help companies successfully transition to D2C models.
The production of liquid-gas mixtures with desired properties still places high demands on process technology and is usually realized in bubble columns. The physical calculation models used have individual dimensionless factors which, depending on the application, are only valid for small ranges consisting of flow velocity, nozzle geometry and test setup. An iterative but time-consuming design of such dispersion processes is used in industry for producing a liquid-gas mixture according to desired requirements. In the present investigation, we accelerate the necessary design loops by setting up a physical model, which consists of several subsystems that are enriched by dedicated experiments to realize liquid-gas dispersions with low volume fraction and small air bubble diameters in oil. Our approach allows the extraction of individual dimensionless factors from maps of the introduced subsystems. These maps allow for targeted corrective measures of a production process for keeping the quality. The calculation-based approach avoids the need for performing iterative design loops. Overall, this approach supports the controlled generation of liquid-gas mixtures.
This study aims to address the research gap surrounding the role of leadership in the formation of high-performance teams within startup companies. While there is existing research on high-performing teams, limited attention has been given to leadership in this environment. To bridge this gap, the study combines a literature review and qualitative analysis through semi-structured interviews with diverse stakeholders in startups, with the goal of providing practical guidance for startup executives based on the research findings. The study uncovers key aspects of leadership in high-performance teams, emphasizing the importance of skills such as motivation and support for team members, fostering psychological safety and trust, and effectively managing uncertainty. In addition to resource constraints and high expectations, the study sheds light on the challenges faced by leaders in startup and high-performance team environments, particularly the blurring of traditional leadership roles as team members seek autonomy and decision-making authority. These findings present opportunities for future research to explore this progressive leadership style. Overall, this study contributes to our understanding of leadership dynamics within high-performance teams operating in the context of startups. It offers valuable insights that can help startup executives navigate the complexities of leadership and foster the development of successful and high-performing teams.
This thesis investigates the role of leadership behaviours of C-level executives in the context of post-M&A integration processes. The primary focus is on understanding the impact of specific leadership behaviours on inspiring desirable follower effects and facilitating emotional acceptance during organizational change. Drawing on the frameworks presented in “Six- Dimension Integrative Model of Leadership” and "The Six Domains of Leadership" developed by Sitkin et al., the study conducts expert interviews with managers from middle management who have recently experienced M&A integration. The answers are analysed in depth to identify the most effective leadership behaviours, highlighting those mentioned most frequently and those capable of triggering multiple follower effects simultaneously. The result is a list of behaviours that can serve as a guideline for C-level executives who want to foster desirable follower effects throughout the M&A integration journey.
This thesis aims to determine how banks can prepare for fulfilling and implementing the IFRS S1 requirements, which have been published by the International Sustainability Standard Board. It also examines the extent to which banks in Liechtenstein and Switzerland have already implemented the existing regulatory requirements in the area of sustainability transparency and integrated them into their financial reporting. The focus is to determine whether, and to what extent, these requirements enable banks to disclose relevant information on sustainability aspects in their financial reports. In order to answer the research question appropriately, a qualitative research method according to Mayring was used, which included conducting expert interviews. In this context, it is important to analyze the possibilities of IFRS S1 concerning the identification, assessment, and disclosure of sustainability risks and opportunities. The thesis also analyzes the impact of the regulatory requirements on banks, including the challenges of implementing IFRS S1 and the potential benefits and opportunities for banks of complying with the sustainability transparency requirements. The results are intended to develop a better understanding of how the regulatory requirements for sustainability transparency can be effectively used by banks to improve the quality and comparability of sustainability-related financial information under IFRS S1.
In 2021, a prominent Austria dairy producer suffered from an IT attack and was completely paralysed. Without clearly defined mitigation measures in place, major disruptions were caused alongside the whole supply chain, including logistics service providers, governmental food safety bodies, as well as retailers (i.e., supermarkets and convenience stores). In this paper, we ask the question how digitisation and digital transformation impact IT security, especially when considering the complex company ecosystems of food production and food supply chains in Austria. The problem statement stems from a gap in knowledge of key differences in approaches towards IT security, resilience, risk management and especially business interfaces between food suppliers, supermarkets, distributors, logistics and other service providers. In order to answer related research questions, firstly, the authors conduct literature research, and highlight common guidelines and standardisation as well as look at state-based recommendations for critical infrastructure. In a second step, the paper describes a quantitative and qualitative survey with Austrian food companies (producers and retailers) which is described in detail in the paper. A description of recommended measures for the industry, further steps, as well as an outlook conclude the paper.
The control measures for the COVID-19 pandemic, early 2020, caused a chain reaction that eventually led to a shortage of components in the electronic manufacturing industry. A lack of components meant that the production and sales were interrupted or even stopped. For many electronic manufacturing firms, this was seen as a crisis. A crisis is mostly divided into three phases called the pre-crisis phase, crisis management and post-crisis phase. The pre-crisis phase involves an environmental assessment and setting up of crisis management teams, and plan. The crisis management phase has to do with the collection and interpretation of information and the mitigation of the crisis. The post-crisis phase looks at learnings from the crisis. In this paper it was investigated how the electronic manufacturing firms in Vorarlberg managed the crisis in the period between 2020 and 2022. The overall aim was to get a full understanding of how it affected the operations regarding the respective crisis teams and which factors were considered most important for setting up the teams. Two basic criteria which had to be over-come was the uncertainty and lack of time. It was seen that even though the fundamental structure did not change, crisis teams were added in the form of a crisis management team and task forces. The task forces played a major role in getting an understanding of the problem and the effect it has on the business. The crisis management team, which includes high level managers from all affected functional areas, had to re-evaluate the high level strategy and decide what needs to be done, and who will be doing it. In order to do so, they needed to understand what the priorities are regarding components and products and then decide on the priorities regarding affected business. The new strategy was then handed down to the task forces for implementation. A major focus of this paper was also on decision making and how everything contributed to making decisions that had the right effect in resolving the financial crisis for the organizations.
Measuring what matters
(2023)
Patient reported outcomes (PROs) are generally defined as ‘any report of the status of a patient's health condition that comes directly from the patient, without interpretation of the patient's response by a clinician or anyone else’. A broader definition of PRO also includes ‘any information on the outcomes of health care obtained directly from patients without modification by clinicians or other health care professionals’. Following this approach, PROs encompass subjective perceptions of patients on how they function or feel not only in relation to a health condition but also to its treatment as well as concepts such as health-related quality of life (HrQoL), information on the functional status of a patient, signs and symptoms and symptom burden. PRO measurement instruments (PROMs) are mostly questionnaires and inform about what patients can do and how they feel. PROs and PROMs have not yet found unconditional acceptance and wide use in the field of inborn errors of metabolism. This review summarises the importance and usefulness of PROs in research, drug legislation and clinical care and informs about quality standards, development, and potential methodological shortfalls of PROMs. Inclusion of PROs measured with high-quality, well-selected PROMs into clinical care, drug legislation, and research helps to identify unmet needs, improve quality of care, and define outcomes that are meaningful to patients. The field of IEM should open to new methodological approaches such as the definition of core sets of variables including PROs to be systematically assessed in specific metabolic conditions and new collaborations with PRO experts, such as psychologists to facilitate the systematic collection of meaningful data.
Creating a schedule to perform certain actions in a realworld environment typically involves multiple types of uncertainties. To create a plan which is robust towards uncertainties, it must stay flexible while attempting to be reliable and as close to optimal as possible. A plan is reliable if an adjustment to accommodate for a new requirement causes only a few disruptions. The system needs to be able to adapt to the schedule if unforeseen circumstances make planned actions impossible, or if an unlikely event would enable the system to follow a better path. To handle uncertainties, the used methods need to be dynamic and adaptive. The planning algorithms must be able to re-schedule planned actions and need to adapt the previously created plan to accommodate new requirements without causing critical disruptions to other required actions.
Digitalization is changing business models and operational processes. At the same time, improved data availability and powerful analytical methods are influencing controlling and increasingly require the use of statistical and information technology skills and knowledge. Using a case study from marketing controlling, the article shows the use of business analytics methods and addresses the tasks of controlling in the digital age.
Demand-side management approaches that exploit the temporal flexibility of electric vehicles have attracted much attention in recent years due to the increasing market penetration. These demand-side management measures contribute to alleviating the burden on the power system, especially in distribution grids where bottlenecks are more prevalent. Electric vehicles can be defined as an attractive asset for distribution system operators, which have the potential to provide grid services if properly managed. In this thesis, first, a systematic investigation is conducted for two typically employed demand-side management methods reported in the literature: A voltage droop control-based approach and a market-driven approach. Then a control scheme of decentralized autonomous demand side management for electric vehicle charging scheduling which relies on a unidirectionally communicated grid-induced signal is proposed. In all the topics considered, the implications on the distribution grid operation are evaluated using a set of time series load flow simulations performed for representative Austrian distribution grids. Droop control mechanisms are discussed for electric vehicle charging control which requires no communication. The method provides an economically viable solution at all penetrations if electric vehicles charge at low nominal power rates. However, with the current market trends in residential charging equipment especially in the European context where most of the charging equipment is designed for 11 kW charging, the technical feasibility of the method, in the long run, is debatable. As electricity demand strongly correlates with energy prices, a linear optimization algorithm is proposed to minimize charging costs, which uses next-day market prices as the grid-induced incentive function under the assumption of perfect user predictions. The constraints on the state of charge guarantee the energy required for driving is delivered without failure. An average energy cost saving of 30% is realized at all penetrations. Nevertheless, the avalanche effect due to simultaneous charging during low price periods introduces new power peaks exceeding those of uncontrolled charging. This obstructs the grid-friendly integration of electric vehicles.
Open tracing tools
(2023)
Background: Coping with the rapid growing complexity in contemporary software architecture, tracing has become an increasingly critical practice and been adopted widely by software engineers. By adopting tracing tools, practitioners are able to monitor, debug, and optimize distributed software architectures easily. However, with excessive number of valid candidates, researchers and practitioners have a hard time finding and selecting the suitable tracing tools by systematically considering their features and advantages. Objective: To such a purpose, this paper aims to provide an overview of popular Open tracing tools via comparison. Methods: Herein, we first identified 30 tools in an objective, systematic, and reproducible manner adopting the Systematic Multivocal Literature Review protocol. Then, we characterized each tool looking at the 1) measured features, 2) popularity both in peer-reviewed literature and online media, and 3) benefits and issues. We used topic modeling and sentiment analysis to extract and summarize the benefits and issues. Specially, we adopted ChatGPT to support the topic interpretation. Results: As a result, this paper presents a systematic comparison amongst the selected tracing tools in terms of their features, popularity, benefits and issues. Conclusion: The result mainly shows that each tracing tool provides a unique combination of features with also different pros and cons. The contribution of this paper is to provide the practitioners better understanding of the tracing tools facilitating their adoption.
A rapid change to remote work during the beginning of the Covid-19 pandemic allowed many organizations to roll out new collaboration platforms to rapidly digitalize their workflows and processes in order to continue operation. This sudden shift to remote work revealed to employees the potential benefits of working remotely in the form of additional flexibility and also showed the challenges and barriers organizations could face by introducing such a strategy. This thesis aims to uncover the key considerations that the organizations of the industrial sector in Vorarlberg need to consider establishing a remote work strategy. According to the results from the research, the Covid-19 pandemic was as a paradigm change for the interviewed decision makers about how they thought about remote work and how they transformed their respective organizations too continue to operate. After the initial phase of Covid-19 restrictions organizations started to experiment with a remote work strategy of their own, based on their past experiences. For now, most of the interviewed organizations use already different remote work concepts and evaluate which one suits best their needs. The main considerations as to why an organization introduced a remote work strategy are to be an attractive employer and to stay ahead in the search for new talent. Further by introducing a remote work strategy, organizations need to change their rules of collaboration, adapt their core values to fit a remote workplace and to introduce collaboration platforms which are designed to support a remote workforce.
Tap or swipe
(2023)
Having autonomy in the workplace can have a positive impact on employees’ performance, which in turn can benefit the organization’s competitive advantages. While previous researches have primarily focused on the psychological effects of job autonomy on employee performance and has been limited to certain domains, the relationship between job autonomy and organizational design is an important area of study for organizations seeking to improve their competitiveness. This thesis proposes a conceptual model for designing an organization structure that promotes employee performance in manufacturing companies by removing obstacles towards obtaining job autonomy. The focus is on ambitious employees who seek growth and development opportunities within their organization. The model is based on a review of existing literature on job autonomy and organizational design. Exploratory qualitative research was conducted with selected ambitious employees from different industries by means of one-on-one semi-structured interviews. Overall, the proposed model has practical implications for manufacturing companies looking to motivate their employees, as well as for researchers seeking to advance their understanding of organizational design in our times.
Purpose – The purpose of this study is to explore the exogenous and endogenous drivers of the high-growth of Unicorn start-ups along their life cycle, with a particular focus on Unicorns in the fintech industry.
Design/methodology/approach – The study employs an explorative longitudinal analysis with a matched pair of two cases of Unicorns start-ups with similar antecedent features to understand holistically drivers over the longer term.
Findings – High-growth patterns over the longer term are the result of a combined industry- and company-life cycle perspective. Drivers and growth patterns vary significantly according to the time of entry in the industry and
its development status. The findings are systematised within a set of propositions to be tested in future research.
Research limitations/implications – The limitations lie in empirical evidence, as the analysis is limited to one matched-pair. The revealed Unicorns’ drivers for long-term growth might encourage future research to further investigate these drivers on a larger scale.
Practical implications – The study offers practical recommendations for start-ups with high-growth ambitions and advice to policy makers regarding the development of tailor-made support programs.
Originality/value – The study significantly extends extant work on growth and high-growth by examining endogenous and exogenous triggers over time and by linking the Unicorn-life cycle to the industry life cycle, an approach which has, to the best of the authors’ knowledge, not yet been applied.
In the era of digital transformation an evolution takes place. Following this, new perspectives concerning leadership are required, especially in virtual teams. Shared Leadership is a promising leadership form to meet the challenges in a virtual team setting. Particularly, studies show that shared leadership increases performance, team creativity and innovative behavior. Moreover, the responsibility is distributed among several, not one individual. Nevertheless, it is unclear, which skills are needed in shared leadership teams and how they could be trained. Therefore, we develop a conceptual framework to pave the way for an empirical inquiry of the skills for and the role of shared leadership. Moreover, we encourage the discussion, whether the current leadership development is still viable and offer practical implications to develop shared leadership.
The thorny issue of time
(2023)
Synthetic polymers, such as polyamide (PA), inherently possess a moderate number of surface functionalities compared to natural polymers, which negatively impacts the uniformity of metallic coatings obtained through wet-chemical methods like electroless plating. The paper presents the use of a siloxane interlayer formed from the condensation of the hydrolyzed 3-triethoxysilylpropyl succinic anhydride (TESPSA) precursor as a strategy to modify the surface properties of polyamide 6.6 (PA66) fabrics and improve the uniformity of the copper surface coating. The application of the siloxane intermediate coating demonstrates a significant improvement in electrical conductivity, up to 20 times higher than fabrics without the interlayer. The morphology of the coatings was investigated using scanning electron (SEM) and laser confocal scanning microscopy (LSM). In addition, dye adsorption, flexural rigidity, air permeability and contact angle measurements were conducted to monitor the change in the PA66 properties after the siloxane functionalization.
Beyond the Four-Level Model: Dark and Hot States in Quantum Dots Degrade Photonic Entanglement
(2023)
Entangled photon pairs are essential for a multitude of quantum photonic applications. To date, the best performing solid-state quantum emitters of entangled photons are semiconductor quantum dots operated around liquid-helium temperatures. To favor the widespread deployment of these sources, it is important to explore and understand their behavior at temperatures accessible with compact Stirling coolers. Here we study the polarization entanglement among photon pairs from the biexciton–exciton cascade in GaAs quantum dots at temperatures up to ∼65 K. We observe entanglement degradation accompanied by changes in decay dynamics, which we ascribe to thermal population and depopulation of hot and dark states in addition to the four levels relevant for photon pair generation. Detailed calculations considering the presence and characteristics of the additional states and phonon-assisted transitions support the interpretation. We expect these results to guide the optimization of quantum dots as sources of highly entangled photons at elevated temperatures.
Programmable Logic Controller (PLC) modules are used in industrial settings to control and monitor various manufacturing processes. Detecting these modules can be helpful during installation and maintenance. However, the limited availability of real annotated images to train an object detector poses a challenge. This thesis aims to research object detection of these modules on real images by using synthetic data during training. The synthetic images are generated from CAD models and improved with Generative Adversarial Networks (GANs). The CAD models are rendered in different scenes, and perfectly annotated images are automatically saved. A technique called domain randomization is applied during rendering. It renders the modules in different poses with constantly changing backgrounds. As the CAD models do not visually resemble the real modules, it is necessary to improve the synthetic images. This project researches StarGAN and CycleGAN for the task of image-to-image translation. A GAN is trained with real and synthetic images and can then translate between these domains. YOLOv8 and Faster R-CNN are tested for object detection. The best mean Average Precision (mAP) is achieved when training with a synthetic dataset where 50% of the images were improved with StarGAN. When trained with YOLOv8 and evaluated on a real dataset, it achieves a mAP of 84.4%. Overall, the accuracy depends on the quality of the CAD models. Using a GAN improves the detection rate for all modules, but especially for unrealistic CAD models.
X-ray microtomography is a nondestructive, three-dimensional inspection technique applied across a vast range of fields and disciplines, ranging from research to industrial, encompassing engineering, biology, and medical research. Phasecontrast imaging extends the domain of application of x-ray microtomography to classes of samples that exhibit weak attenuation, thus appearing with poor contrast in standard x-ray imaging. Notable examples are low-atomic-number materials, like carbon-fiber composites, soft matter, and biological soft tissues.We report on a compact and cost-effective system for x-ray phase-contrast microtomography. The system features high sensitivity to phase gradients and high resolution, requires a low-power sealed x-ray tube, a single optical element, and fits in a small footprint. It is compatible with standard x-ray detector technologies: in our experiments, we have observed that single-photon counting offered higher angular sensitivity, whereas flat panels provided a larger field of view. The system is benchmarked against knownmaterial phantoms, and its potential for soft-tissue three-dimensional imaging is demonstrated on small-animal organs: a piglet esophagus and a rat heart.We believe that the simplicity of the setupwe are proposing, combined with its robustness and sensitivity, will facilitate accessing quantitative x-ray phase-contrast microtomography as a research tool across disciplines, including tissue engineering, materials science, and nondestructive testing in general.
In an oversaturated market, companies are required to use innovative and, above all, creative advertising methods to capture their customers’ attention, and thus differentiate themselves from rival businesses. To this end, companies have been increasingly relying on the use of humor, a phenomenon that remains highly subjective and is perceived differently by each individual. This master’s thesis, which was completed as part of the International Marketing and Sales program at the FH Vorarlberg, focuses on this phenomenon of humor as well as its impact on advertising perception. With the aid of three different theories, the term “humor” is defined. Furthermore, this study explains and researches the so-called vampire effect, wherein various factors (in this case humor) draw attention away from the actual advertising message. In addition, this thesis takes a closer look at involvement, as a person’s involvement or interest in a brand or product can influence brand and product recall and recognition. An online survey was conducted to determine whether the vampire effect caused by humor is able to influence brand and product recall. In other words, this concerns whether the viewer can still remember the brand and product afterward or whether the humor employed triggers the vampire effect. Furthermore, this thesis explored whether the vampire effect caused by humor is able to influence brand and product recognition. Recall is the retrieval of information from memory without direct cues, whereas recognition refers to the recognition of information when it is presented again. Furthermore, within this context, it was discovered that brand and product recall varies with low and high involvement viewers of the advertisement. In other words, this means that the strength of the vampire effect caused by humor changes depending on the strength of the viewer’s involvement. During the course of this research, it was further observed that the humor employed significantly affects the perception of the advertising message, thus confirming the existence of the vampire effect. This effect also influences both brand as well as product recall and recognition. In both cases, participants in the survey were less able to remember the product and brand in the humorous advertising. Furthermore, it was proven that people with low involvement in the advertised product group are more heavily affected by the vampire effect. As such, they are more likely to not remember the product or brand after seeing the advertisement.