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Development of a low pressure syringe pump for detecting cannabinoids through liquid chromatography
(2022)
The following thesis covers the miniaturization and characterization of a pneumatic syringe pump, which is used for applications in low-pressure liquid chromatography. For this purpose, the components of the prototype are dealt with in the first section. These include the membrane pump and the cylinder for pressure and force generation, the syringe used for sample preparation and the construction of the test column. Furthermore, the pressure preparation on the cylinder, the friction losses of the syringe and then the behavior of the syringe in various application scenarios are considered. In the second section, the focus is on the different behaviors when using water and ethanol as a solvent. Tests in normal applications, as well as with air pockets or leaking seals, show the different behavior and the resulting deviations in the test pressure of the column. In addition, the maximum forces that can be applied to the syringe are worked out in several tests and the different maximum pressures, which depend on the solvent contained, are evaluated. These different maximum pressures, which are due to the different sealing behavior in connection with the surface tension of the liquid, will be discussed in conclusion. An outlook follows, up to which test pressures the system can be used and how these can be achieved.