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In this paper, we consider the question of data aggregation using the practical example of emissions data for economic activities for the sustainability assessment of regional bank clients. Given the current scarcity of company-specific emission data, an approximation relies on using available public data. These data are reported in different standards in different sources. To determine a mapping between the different standards, an adaptation to the Covariance Matrix Self-Adaptation Evolution Strategy is proposed. The obtained results show that high-quality mappings are found. Nevertheless, our approach is transferable to other data compatibility problems. These can be found in the merging of emissions data for other countries, or in bridging the gap between completely different data sets.
HINTERGRUND: Gesundheitsförderungsforschung und ‐ausbildung sind zentrale Hebel für Kapazitätsentwicklung und Voraussetzungen für eine qualitätsgesicherte Gesundheitsförderungspraxis. Das Kompetenzzentrum Zukunft Gesundheitsförderung im Fonds Gesundes Österreich hat als eine Aufgabe, Capacity Building für Gesundheitsförderung (GF) in Österreich zu unterstützen und weiterzuentwickeln. Das Diskussionspapier widmet sich der Frage, welche Maßnahmen es braucht, um die Ausbildung und Forschung in Österreich weiterzuentwickeln und zu stärken. ***METHODE: Aufbauend auf der Fallstudie zu Forschungsaktivitäten an (Privat‐)Universitäten, FHs, außeruniversitären Forschungseinrichtungen sowie Aktivitäten im Bereich Ausbildung zu einzelnen tertiären Studienangeboten mit explizitem GF‐Bezug (Plunger/Wahl 2023; Wahl/Plunger 2023) wurden mit Expertinnen und Experten aus den Bereichen Ausbildung, Forschung und Praxis im Rahmen von drei Workshops und zwei schriftlichen Feedbackschleifen Entwicklungsperspektiven zur Gesundheitsförderungsausbildung und ‐forschung entwickelt. ***ERGEBNISSE: Im Diskussionspapier wurden für die Bereiche Ausbildung und Forschung jeweils drei zentrale Entwicklungsperspektiven benannt und hinsichtlich eines Zielbilds, des Nutzens und der Realisierungsmöglichkeiten beschrieben: Im Bereich Ausbildung sind das die Stärkung der Vernetzung der Ausbildungs‐, Forschungs‐ und Praxiseinrichtungen, die Entwicklung und Etablierung von Kernkompetenzen in der Gesundheitsförderung und die (Weiter‐)Entwicklung spezialisierter Ausbildungsangebote und Lehrformate für Gesundheitsförderung. Für den Bereich Forschung sind das die Stärkung langfristiger finanzieller Ressourcen, die Stärkung von Strukturen für die Verbindung von Forschung, Policy und Praxis sowie die Stärkung von (Nachwuchs‐)Wissenschaftlerinnen, (Nachwuchs‐)Wissenschaftlern und des Forschungsumfelds für Gesundheitsförderungsforschung. Die einzelnen Perspektiven sind zum Teil eng miteinander verbunden und können einander stärken. Übergreifend braucht es sowohl für die Ausbildung als auch für die Forschung Advocacy‐Arbeit und Sensibilisierungsarbeit unter Expertinnen, Experten, Entscheidungsträgerinnen und ‐trägern sowie ausreichend finanzielle Ressourcen und Rahmenbedingungen, die die beschriebenen Entwicklungen ermöglichen. Die konkreten Inhalte der Entwicklungsperspektiven sollen in Zukunft unter Einbindung aller relevanten (inter‐)nationalen Akteurinnen und Akteure gestaltet werden.
This study presents different approaches to increase the sensing area of NiO based semiconducting metal oxide gas sensors. Micro- and nanopatterned laser induced periodic surface structures (LIPSS) are generated on silicon and Si/SiO2 substrates. The surface morphologies of the fabricated samples are examined by FE SEM. We select the silicon samples with an intermediate Si3N4 layer due to its superior isolation quality over the thermal oxide for evaluating the hydrogen and acetone sensitivity of a NiO based test sensor.
Objectives: The MetabQoL 1.0 is the first disease-specific health related quality of life (HrQoL) questionnaire for patients with intoxication-type inherited metabolic disorders. Our aim was to assess the validity and reliability of the MetabQoL 1.0, and to investigate neuropsychiatric burden in our patient population. Methods: Data from 29 patients followed at a single center, aged between 8 and 18 years with the diagnosis of methylmalonic acidemia (MMA), propionic acidemia (PA) or isovaleric acidemia (IVA), and their parents were included. The Pediatric Quality of Life Inventory (PedsQoL) was used to evaluate the validity and reliability of MetabQoL 1.0.
Results: The MetabQoL 1.0 was shown to be valid and reliable (Cronbach's alpha: 0.64–0.9). Fourteen out of the 22 patients (63.6%) formally evaluated had neurological findings. Of note, 17 out of 20 patients (85%) had a psychiatric disorder when evaluated formally by a child and adolescent psychiatrist. The median mental scores of the MetabQoL 1.0 proxy report were significantly higher than those of the self report (p = 0.023). Patients with neonatal-onset disease had higher MetabQoL 1.0 proxy physical (p = 0.008), mental (p = 0.042), total scores (p = 0.022); and self report social (p = 0.007) and total scores (p = 0.043) than those with later onset disease.
Conclusions: This study continues to prove that the MetabQoL 1.0 is an effective tool to measure what matters in intoxication-type inherited metabolic disorders. Our results highlight the importance of clinical assessment complemented by patient reported outcomes which further expands the evaluation toolbox of inherited metabolic diseases.
In Bewegung kommen
(2023)
Armut im Blick?
(2023)
Whether at the intramolecular or cellular scale in organisms, cell-cell adhesion adapt to external mechanical cues arising from the static environment of cells and from dynamic interactions between neighboring cells. Cell-cell adhesions need to resist detachment forces to secure the integrity and internal organization of organisms. In the past, various techniques have been developed to characterize adhesion properties of molecules and cells in vitro, and to understand how cells sense and probe their environment. Atomic force microscopy and dual-pipette aspiration, where cells are mainly present in suspension, are common methods for studying detachment forces of cell-cell adhesions. How cell-cell adhesion forces are developed for adherent and environment-adapted cells, however, is less clear. Here, we designed the Cell-Cell Separation Device (CC-SD), a microstructured substrate that measures both intercellular forces and external stresses of cells towards the matrix. The design is based on micropillar arrays originally designed for cell traction-force measurements. We designed PDMS micropillar-blocks, to which cells could adhere and be able to connect to each other across the gap. Controlled stretching of the whole substrate changed the distance between blocks and increased gap size. That allowed us to apply strains to cell-cell contacts, eventually leading to cell-cell adhesion detachment, which was measured by pillar deflections. The CC-SD provided an increase of the gap between the blocks of up to 2.4-fold, which was sufficient to separate substrate-attached cells with fully developed F-actin network. Simultaneously measured pillar deflections allowed us to address cellular response to the intercellular strain applied. The CC-SD thus opens up possibilities for the analysis of intercellular force detachments and sheds light on the robustness of cell-cell adhesions in dynamic processes in tissue development.
Why do some countries assign a major role to wind energy in decarbonizing their electricity systems, while others are much less committed to this technology? We argue that processes of (de-)legitimation, driven by discourse coalitions who strategically employ certain storylines in public debates, provide part of the answer. To illustrate our approach, we comparatively investigate public discourses surrounding wind energy in Austria and Switzerland, two countries that differ strongly in wind energy deployment. By combining a qualitative content analysis and a discourse network analysis of 808 newspaper articles published 2010–2020, we identify four distinct sets of storylines used to either delegitimize or legitimize the technology. Our study indicates that low deployment rates in Switzerland can be related to the prominence of delegitimizing storylines in the public discourse, which result in a rather low socio-political acceptance of wind energy. In Austria, by contrast, there is more consistent support for wind energy by discourse coalitions using a broad set of legitimizing storylines. By bridging the related but separate literatures of technology legitimacy and social acceptance, our study contributes to a better understanding of socio-political conflict and divergence in low-carbon technological pathways.
A step change is needed in the deployment of renewable energy if the triple challenge of ensuring climate change mitigation, energy security, and energy affordability is to be met. Yet, social acceptance of infrastructure projects and policies remains a key concern. While there has been decades of fruitful research on the social acceptance of wind energy and other renewables, much of the extant research is cross-sectional in nature, failing to capture the important dynamic processes that can make or break renewable energy projects. This paper introduces a Special Issue of Energy Policy which focuses on the neglected topic of the dynamics of social acceptance of renewable energy, drawing on contributions made at an international research conference held in St. Gallen (Switzerland) in June 2022. In addition to introducing these papers and drawing out common themes, we also seek to offer some conceptual clarity on the issue of dynamics in social acceptance, taking into account the influence of time, power, and scale in shaping decision-making processes. We conclude by highlighting a number of avenues of potential future research.