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Objectives: The MetabQoL 1.0 is the first disease-specific health related quality of life (HrQoL) questionnaire for patients with intoxication-type inherited metabolic disorders. Our aim was to assess the validity and reliability of the MetabQoL 1.0, and to investigate neuropsychiatric burden in our patient population. Methods: Data from 29 patients followed at a single center, aged between 8 and 18 years with the diagnosis of methylmalonic acidemia (MMA), propionic acidemia (PA) or isovaleric acidemia (IVA), and their parents were included. The Pediatric Quality of Life Inventory (PedsQoL) was used to evaluate the validity and reliability of MetabQoL 1.0.
Results: The MetabQoL 1.0 was shown to be valid and reliable (Cronbach's alpha: 0.64–0.9). Fourteen out of the 22 patients (63.6%) formally evaluated had neurological findings. Of note, 17 out of 20 patients (85%) had a psychiatric disorder when evaluated formally by a child and adolescent psychiatrist. The median mental scores of the MetabQoL 1.0 proxy report were significantly higher than those of the self report (p = 0.023). Patients with neonatal-onset disease had higher MetabQoL 1.0 proxy physical (p = 0.008), mental (p = 0.042), total scores (p = 0.022); and self report social (p = 0.007) and total scores (p = 0.043) than those with later onset disease.
Conclusions: This study continues to prove that the MetabQoL 1.0 is an effective tool to measure what matters in intoxication-type inherited metabolic disorders. Our results highlight the importance of clinical assessment complemented by patient reported outcomes which further expands the evaluation toolbox of inherited metabolic diseases.
Organic acidurias (OAs), urea-cycle disorders (UCDs), and maple syrup urine disease (MSUD) belong to the category of intoxication-type inborn errors of metabolism (IT-IEM). Liver transplantation (LTx) is increasingly utilized in IT-IEM. However, its impact has been mainly focused on clinical outcome measures and rarely on health-related quality of life (HRQoL). Aim of the study was to investigate the impact of LTx on HrQoL in IT-IEMs. This single center prospective study involved 32 patients (15 OA, 11 UCD, 6 MSUD; median age at LTx 3.0 years, range 0.8–26.0). HRQoL was assessed pre/post transplantation by PedsQL-General Module 4.0 and by MetabQoL 1.0, a specifically designed tool for IT-IEM. PedsQL highlighted significant post-LTx improvements in total and physical functioning in both patients' and parents' scores. According to age at transplantation (≤3 vs. >3 years), younger patients showed higher post-LTx scores on Physical (p = 0.03), Social (p < 0.001), and Total (p =0.007) functioning. MetabQoL confirmed significant post-LTx changes in Total and Physical functioning in both patients and parents scores (p ≤ 0.009). Differently from PedsQL, MetabQoL Mental (patients p = 0.013, parents p = 0.03) and Social scores (patients p = 0.02, parents p = 0.012) were significantly higher post-LTx. Significant improvements (p = 0.001–0.04) were also detected both in self- and proxy-reports for almost all MetabQoL subscales. This study shows the importance of assessing the impact of transplantation on HrQoL, a meaningful outcome reflecting patients' wellbeing. LTx is associated with significant improvements of HrQol in both self- and parentreports. The comparison between PedsQL-GM and MetabQoL highlighted that MetabQoL demonstrated higher sensitivity in the assessment of diseasespecific domains than the generic PedsQL tool.
A Telecom optical fibers are still being the best transmission medium of digital data and analogue signals for long distance applications. Progress in integrated photonics enables development of photonic chips with new unique properties, circuits of the future, and overcomes current limits in information and communication technologies. The packaging of photonic chips is necessary for taking them out of research laboratories into real implementation in the information and communication technology applications. One important step of packaging is effective coupling of optical radiation between telecom optical fiber with ten microns core dimension and photonic chip optical waveguide with submicron dimensions. For complex photonic chips, it is necessary to couple not one optical fiber but several optical fibers, which are arranged in fiber arrays. In this case, it is necessary to use a 6D positioning system, which allows to optimally adjust the relative position of the photonic chip and the fiber arrays. After setting the optimal relative position of the photonic chip and the fiber array, the process of their fixation follows. One possibility of fixation is gluing with an adhesive in the optical path between the photonic chip and an array of optical fibers with a refractive index close to the refractive index of the optical fiber core. This paper is focused on the experimental test set-up for the temperature characterization of fiber array to photonics chip butt coupling at 1310 nm and 1550 nm wavelengths fixed themselves by UV adhesive in the optical path. The main aims of this works are selection of better adhesive from two types for gluing of photonic chip and fiber array in packaging process of photonics chips and validation of gluing process developing. The coupling and alignment of fiber arrays to photonics chip were done by automated active alignments system and they were fixed themselves by curable epoxy adhesive. Temperature changes of coupling insertion losses are measured and investigated for two different UV adhesives during three temperature cycles from -40 °C to 80 °C in climatic chamber according to Telcordia. Spectral dependence of insertion losses were measured and compared before and after three temperature cycles for 1530 nm to 1570 nm spectral range at room temperature.
This work was supported by the Slovak Research and Development Agency under the contracts APVV-17-0662 and SK-AT-20-0017 and by the COST Action “European Network for High Performance Integrated Microwave Photonics” (EUIMWP) CA16220.
Der Einsatz von Robotik im Pflegekontext wird kontrovers diskutiert und löst unterschiedliche Assoziationen aus. In diesem Beitrag stellen wir Ergebnisse aus einer schriftlichen Befragung bei Pflegekräften aus Deutschland vor. Es wird aufgezeigt, für welche Funktionen und Aufgaben sich Pflegekräfte den Einsatz von Roboter vorstellen können und wo gegensätzliche Einstellungen gegenüber Robotern bestehen. Ein Fallbeispiel illustriert ein mögliches Anwendungsfeld. Mit den reflexiven Fragen laden wir die:den Lesenden ein, sich selbst mit der Idee Roboter als Alltagshelfer für ältere Menschen auseinanderzusetzen.
Rückblicke zur 5. ogsaTAGUNG
(2021)
Quasilineare Tauchankerspule
(2020)
When it comes to improving the health of the general population, mHealth technologies with self-monitoring and intervention components hold a lot of promise. We argue, however, that due to various factors such as access, targeting, personal resources or incentives, self-monitoring applications run the risk of increasing health inequalities, thereby creating a problem of social justice. We review empirical evidence for “intervention-generated” inequalities, present arguments that self-monitoring applications are still morally acceptable, and develop approaches to avoid the promotion of health inequalities through self-monitoring applications.
Ordnung aus der Mitte
(2021)
This paper presents design, simulation, and optimization of the three-dimensional 1×4 optical multimode interference splitter using IP-Dip polymer as a core and polydimethylsiloxane (PDMS) Sylgard 184 as a cladding. The splitter was simulated by using beam propagation method in BeamPROP simulation engine of RSoft photonic tool and optimized for an operating wavelength of 1.55 µm. According to the minimum insertion loss, the dimensions of the MMI coupler and the length of the whole MMI splitter structure were optimized applying a waveguide with a core size of 4×4 µm2. The objective of the study is to create a design for fabrication by three-dimensional direct laser writing optical lithography.
Coupling is one of the most frequently mentioned metric in software systems. However, to measure logical coupling between microservices, runtime information is needed or the availability of service-log files to analyze the calls between services is required. This work presents our emerging results, in which we propose a metric to statically calculate logical coupling between microservices based on commits to versioning systems. We performed an initial validation of the proposed metric with a dataset containing 145 open-source microservices projects. The results illustrate how logical coupling affects every system and increases overtime. However, we did not find a correlation between the number of commits or the number of developers and the introduction of logical coupling. In future, we investigate why, how, and when logical coupling is introduced in a system.
In this work, parametric excitation is introduced in a fully balanced flexible rotor mounted on two identical active gas foil bearings. The active gas foil bearings change the top foil shape harmonically with a specific amplitude and frequency. The deformable foil shape is approximated by an analytical function, while the gas pressure distribution is evaluated by the numerical solution of the Reynolds equation for compressible flow. The harmonic variation of the foil shape generates a respective variation in the bearings’ stiffness and damping properties and the system experiences parametric resonances and antiresonances in specific excitation frequencies. The nonlinear gas bearing forces generate bifurcations in the solutions of the system at certain rotating speeds and excitation frequencies; period doubling and Neimark-Sacker bifurcations are noticed in the examined system, and their progress is evaluated as the two bifurcation parameters (rotating speed and parametric excitation frequency) are changed, though a codimension-2 numerical continuation of limit cycles. It is found that at specific range of excitation frequency there are parametric anti-resonances and the bifurcations collide and vanish. Therefore, a bifurcation-free operating range is established and the system can operate stable at a wide speed range.
Steigende Komplexität von Geschäftsmodellen und in der Niedrigzinsphase stets zulegende Renditeerwartungen an kapitalmarktorientierte Unternehmen führen dazu, dass sich deren Berichterstattung anpasst. Unter anderem ist eine verstärkte Verbreitung und Anwendung von Key Performance Indicators (alternative Führungsgrößen) in der Praxis zu beobachten. Wenigen, zwar prägnanten, aber eben nicht einheitlich definierten oder gar nach geltenden Rechnungslegungsnormen objektiv zu gewinnende Messgrößen kommt eine gesteigerte Bedeutung im externen Berichtswesen zu. Der Beitrag liefert eine Bestandesaufnahme der meist verwendeten Key Performance Indicators in der Praxis in Deutschland, in Österreich und in der Schweiz.
In this paper, we consider the question of data aggregation using the practical example of emissions data for economic activities for the sustainability assessment of regional bank clients. Given the current scarcity of company-specific emission data, an approximation relies on using available public data. These data are reported in different standards in different sources. To determine a mapping between the different standards, an adaptation to the Covariance Matrix Self-Adaptation Evolution Strategy is proposed. The obtained results show that high-quality mappings are found. Nevertheless, our approach is transferable to other data compatibility problems. These can be found in the merging of emissions data for other countries, or in bridging the gap between completely different data sets.
This paper examines the determinants of subnational location choice of Japanese multinational enterprises (JMNEs) in India to investigate whether or not conventional investment behaviour as ‘foot-loose’ and one-off investments has given way to an agglomeration logic as Japanese foreign direct investment has intensified. Using geographic information system analysis of investment project numbers, we find that Japanese MNE behaviour in India is evolving, with complementing but complex subnational interactions of economic, institutional and infrastructure factors serving as strong determinants of location choice consistently across key phases of India’s liberalization. We argue that Japanese investment decisions in India have followed a self-reinforcing dynamic whereby prior investments indeed attract further investment.
In this work, we investigated the influence of different etch depths of the rib waveguides on the performance of SiN-based AWGs. For this purpose, an 8-channel 100 GHz AWG was designed for a center wavelength of 850 nm. The design parameters entered were calculated using the AWG-Parameters tool. The simulations were performed with a commercial photonic tool PHASAR from Optiwave. The simulated performance was evaluated using the AWG-Analyzer tool. For the AWG design, we used three identical rib waveguides with different etch depths to simulate possible etch imperfection. The simulations show the wavelength shift and degradation of the AWG performance.
In the era of digital transformation an evolution takes place. Following this, new perspectives concerning leadership are required, especially in virtual teams. Shared Leadership is a promising leadership form to meet the challenges in a virtual team setting. Particularly, studies show that shared leadership increases performance, team creativity and innovative behavior. Moreover, the responsibility is distributed among several, not one individual. Nevertheless, it is unclear, which skills are needed in shared leadership teams and how they could be trained. Therefore, we develop a conceptual framework to pave the way for an empirical inquiry of the skills for and the role of shared leadership. Moreover, we encourage the discussion, whether the current leadership development is still viable and offer practical implications to develop shared leadership.
In Bewegung kommen
(2023)
Highly-sensitive single-step sensing of levodopa by swellable microneedle-mounted nanogap sensors
(2022)
Microneedle (MN) sensing of biomarkers in interstitial fluid (ISF) can overcome the challenges of self-diagnosis of diseases by a patient, such as blood sampling, handling, and measurement analysis. However, the MN sensing technologies still suffer from poor measurement accuracy due to the small amount of target molecules present in ISF, and require multiple steps of ISF extraction, ISF isolation from MN, and measurement with additional equipment. Here, we present a swellable MN-mounted nanogap sensor that can be inserted into the skin tissue, absorb ISF rapidly, and measure biomarkers in situ by amplifying the measurement signals by redox cycling in nanogap electrodes. We demonstrate that the MN-nanogap sensor measures levodopa (LDA), medication for Parkinson disease, down to 100 nM in an aqueous solution, and 1 μM in both the skin-mimicked gelatin phantom and porcine skin.
Welche Politikziele geben Fachkräfte der Sozialen Arbeit an Eltern weiter, konkret was wird in Beratungen von Eltern explizit und implizit thematisiert und empfohlen? Der Artikel fokussiert auf die Herstellung von Geschlechterarrangements im Rahmen von Beratungssettings auf zwei Ebenen: einerseits zwischen Fachkräften und Eltern und andererseits zwischen den beratenen Eltern. Ausgehend von einer Heuristik, welche die Wirkung steuerungspolitischer Interventionen als Resultat der Deutung seitens der Adressierten begreift, stellt der Beitrag ein Instrument vor, mit dem Deutungen familienpolitischer Leistungen in der Beratung von Sozialarbeiter:innen und adressierten Eltern reflektiert werden können: das familienpolitische Brettspiel. Damit bietet das Beratungsinstrument eine Hilfestellung zur geschlechtersensiblen Adressierung der Eltern in Bezug auf ihre Arbeitsteilung.
Gender und sexuelle Orientierung im Alter - authentisches Verhalten förderlich für die Gesundheit?
(2021)
Praxisanleiter:innen nehmen eine entscheidende Rolle in der Ausbildung von Pflegepersonen wahr. Die Tätigkeit fordert eine Vielzahl von Kompetenzen. Die Weiterbildung Praxisanleitung bietet eine wichtige Grundlage für die Entwicklung dieser Kompetenzen – deren Rahmenbedingungen, Methoden und Inhalte in Österreich werden in dieser Studie untersucht.
We present design of planar 16-channel, 100-GHz multi-mode polymer-based AWG. This AWG was designed for central wavelength of 1550 nm applying AWG-Parameters tool. The AWG structure was created and simulated in the commercial photonic tool PHASAR from Optiwave. Achieved transmission characteristics were evaluated by AWG-Analyzer tool. For the design, multi-mode waveguides having a cross-section of (4x4) µm2 were used. The simulated results show strong worsening of the transmission characteristics in comparison when using single-mode waveguides. Nevertheless, the transmitting channels are clearly separated. The reason for using thicker multi-mode waveguides in the design is possibility to fabricate the AWG structure on polymer basis using direct laser writing lithography.
The paper deals with designing and numerical modelling a 2 x 2 optical switch for photonic integrated circuits based on 2 x 2 MMI elements and phase modulators. The 2 x 2 optical switch was modelled in the RsoftCAD with the simulation tool BeamPROP. The 2 x 2 optical switch is a common element for creating more complex 1 x N or N x N optical switches in all-optical signal processing.
Statistische Methodenkompetenz wird im Controlling zunehmend bedeutender, so ist die evidenzbasierte Prognose durch algorithmische Analyse von Datenbeständen ein Schwerpunkt von Controlling Analytics. Die Fallstudie durchleuchtet daher anhand von Datenmaterial des Schweizer Bundesamts für Statistik das Vorgehen bei einer Datenanalyse, insbesondere beim Einsatz der Zeitregression für Prognosezwecke, und geht dabei auf methodische Besonderheiten, Caveats und Einsatzmöglichkeiten in Microsoft Excel ein. Die Fallbeschreibung und Aufgaben sind im WiSt-Heft Nr. 4/23 zu finden.
Controlling Analytics: Einsatz für Prognosen im Controlling - Teil 1: Fallbeschreibung und Aufgaben
(2023)
Statistische Methodenkompetenz wird im Controlling zunehmend bedeutender, so ist die evidenzbasierte Prognose durch algorithmische Analyse von Datenbeständen ein Schwerpunkt von Controlling Analytics. Die Fallstudie durchleuchtet daher anhand von Datenmaterial des Schweizer Bundesamts für Statistik das Vorgehen bei einer Datenanalyse, insbesondere beim Einsatz der Zeitregression für Prognosezwecke, und geht dabei auf methodische Besonderheiten, Caveats und Einsatzmöglichkeiten in Microsoft Excel ein.