Refine
Year of publication
Document Type
- Conference Proceeding (68)
- Article (67)
- Part of a Book (13)
- Report (11)
- Doctoral Thesis (4)
- Book (2)
- Working Paper (2)
- Other (1)
Institute
- Forschungszentrum Business Informatics (168) (remove)
Is part of the Bibliography
- yes (168) (remove)
Keywords
- Evolution Strategies (5)
- Volatile organic compounds (5)
- Constrained Optimization (4)
- Stress testing (4)
- Evolution strategies (3)
- Evolution strategy (3)
- Fragmentation patterns (3)
- Global optimization (3)
- Humans (3)
- Optimization (3)
Product ion distributions resulting from the primary reactions of H3O+ with nine D-labeled volatile organic compounds and the subsequent sequential reactions with H2O have been determined using a Proton Transfer Reaction Time of Flight Mass Spectrometer (PTR-TOF 8000 (IONICON Analytik GmbH)) at various reduced electric field (E/N) values ranging from 80 up to 150 Td and for two different absolute humidity levels of air sample < 0.1% and 5%. The specific D-labeled compounds used in this study are acetone-d6, toluene-d8, benzene-d6, ethanol-d (C2H5OD), ethanol-d2 (CH3CD2OH), ethanol-d6, 2-propanol-d8, 2-propanol-d3 (CD3CH(OH)CH3), and isoprene-d5 (CH2CHC(CD2)CD3). With the exception of the two 2-propanol compounds, non-dissociative proton transfer is the dominant primary reaction pathway. For 2-propanol-d8 and 2-propanol-d3 the major primary reaction channel involved is dissociative proton transfer. However, unlike their undeuterated counterparts, the primary product ions undergo subsequent deuterium/hydrogen isotope exchange reactions with the ever present water in the drift tube, the extent of which of course depends on the humidity within that tube. This exchange leads to the generation of various isotopologue product ions, the product ion branching percentages of which are also
dependent on the humidity in the drift tube. This results in complex mass spectra and the distribution of product ions leads to issues of reduced sensitivity and accuracy. However, the effect of D/H exchange considerably varies between the compounds under study. In the case of acetone-d6 it is very weak (<1%), because the exchange process is not facile when the deuterium is in the methyl functional group. In comparison, the H3O+/ benzene-d6 (C6D6) reaction and sequential reactions with water result in the production of the isotopologue ions C6Dn(H7-n)+ (where n = 0–6). Changing the value of E/N and/or the humidity in the drift tube considerably affects the amount of the isotope exchange reactions and hence the resulting sequential product ion distributions. An important conclusion of the findings from this work is that care must be taken in the choice of an exogenous deuterated compound for use in breath pharmacokinetic studies using proton transfer reaction mass spectrometry; otherwise the resulting D/H exchange processes impose interpretative problems.
© 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).
To create a map of an unknown area, autonomous robots must follow a strategy to explore the area without knowing the optimal paths to reduce the time needed to map the whole area. To reduce the time to accomplish this task, multiple robots can work together to create a map in a more efficient way. However, without proper coordination, the time a team of autonomous robots needs to explore the unknown area can exceed the time needed by a single robot. To counteract the challenges, a shared infrastructure is needed which extracts useful information for the individual robots out of the shared information of all robots so the exploration can be coordinated. These measures introduce new challenges to the system, concerning the load of the communication infrastructure as well as the overall task of exploring and mapping becoming dependent on the correct communication and robustness of the shared team infrastructure. Therefore, the amount of communication and dependency of each individual robot of the rest of the other robots of the team must be reduced to ensure that the robots can continue working even if the communication with the shared infrastructure fails.
Smart services disrupt business models and have the potential to stimulate the circular economy transition of regions, enabling an environmentally friendly atmosphere for sustainable and innovation-driven growth of regions. Although smart services are powerful means for deploying circular economy goals in industrial practices, there is little systematic guidance on how the adoption of smart services could improve resource efficiency and stimulate smart regional innovation-driven growth, enabled through circular design. Implemented in the scope of Vorarlberg’s smart specialization strategy, this paper contributes to the literature on the circular economy and regional innovation-driven growth by assessing critical factors of the value creation and value capture implemented within the scope of the quadruple helix system. By identifying the main challenges and opportunities of collaborative value creation and value capture in setting-up smart circular economy strategies and by assessing the role of innovation actors within the quadruple helix innovation system, the study provides recommendations and set of guidelines for managers and public authorities in managing circular transition. Finally, based on the analysis of the role of actors in creating shared value and scaling-up smart circular economy practices in the quadruple helix innovation systems, the paper investigates the role of banks as enablers of circular economy innovation-driven regional growth and smart value creation.
The role of entrepreneurs and intrapreneurs in the current zeitgeist is to drive innovation, re-shape rigid, established processes in business as well as for consumers. They use new viewpoints to pioneer new (business) models which focus on ‘smartness’ rather than the purely monetary and short-sighted models of yesteryear. Fostering and supporting the culture of this current zeitgeist is a mayor challenge for entre- and intrapreneurial support infrastructures, namely startup centres and innovation hubs of universities and other public institutions as well as innovation centres of private companies. Hereby, support may range from access to funding over provision of resources such as offices or computing hardware to coaching in the development of business ideas and strategic roadmaps for product and service deployment. In this paper, we focus on describing the status-quo of afore- mentioned support infrastructures in Vorarlberg and the Lake Constance region, then extend the scope to existing (international) approaches for aiding founders and inno- vators in the development of smart services. An analysis of success stories of the Vorarlberg startup centre ‘startupstube’ and other initiatives including their compar- ison to international counterparts builds the basis for a methodological framework for (service science) coaching in entre- and intrapreneurial support infrastructures. The paper is concluded by the description of a framework for choosing the right methods and tools to create service value in entre-/intrapreneurship based upon tested, proven know-how and for defining support infrastructure needs based upon pre-defined stakeholder and target groups as well as the (industry) sectors of the innovators.